CAJ | 학술논문

目的：观察微量泵静脉注射硝酸甘油和盐酸尼卡地平治疗肾性高血压急症的疗效和安全性。方法：将肾性高血压急症患者86例随机分为A、B两组，A组43例给予硝酸甘油50 mg配伍到40 mL生理盐水中，应用输液泵30～66．7μg／min静脉泵入治疗；B组43例给予盐酸尼卡地平10 mg配伍到40 mL生理盐水中，应用输液泵30～66．7μg／min静脉泵入治疗，记录治疗前及治疗后60 min收缩压、舒张压、心率变化及不良反应。结果：治疗后60 min时两组收缩压、舒张压、心率变化比较有统计学差异（P＜0．05）；治疗后60 min时与同组治疗前比较，收缩压、舒张压均下降（P＜0．01），心率增快（P＜0．01）。两组不良反应均较少，主要为头痛及窦性心动过速。结论：微量泵静脉泵入硝酸甘油治疗肾性高血压急症疗效优于尼卡地平，未见严重不良反应，可以临床推广应用。
목적：관찰미량빙정맥주사초산감유화염산니잡지평치료신성고혈압급증적료효화안전성。방법：장신성고혈압급증환자86례수궤분위A、B량조，A조43례급여초산감유50 mg배오도40 mL생리염수중，응용수액빙30～66．7μg／min정맥빙입치료；B조43례급여염산니잡지평10 mg배오도40 mL생리염수중，응용수액빙30～66．7μg／min정맥빙입치료，기록치료전급치료후60 min수축압、서장압、심솔변화급불량반응。결과：치료후60 min시량조수축압、서장압、심솔변화비교유통계학차이（P＜0．05）；치료후60 min시여동조치료전비교，수축압、서장압균하강（P＜0．01），심솔증쾌（P＜0．01）。량조불량반응균교소，주요위두통급두성심동과속。결론：미량빙정맥빙입초산감유치료신성고혈압급증료효우우니잡지평，미견엄중불량반응，가이림상추엄응용。
Objective:To observe efficacy and safety of nitroglycerin or nicardipine in therapy of renal hypertensive emergency by intravenous use via mi-cro-pump.Methods:Eighty-six patients with renal hypertensive emergency were randomized into group A and B.Group A(n=43) received nitroglycerin in dose of 50 mg diluted in 40 mL saline through infusion with micro-pump at speed of 30 μg/min to 66.7 μg/min,while group B were given nicardipine in dose of 10 mg diluted in 40 mL saline by intravenous use with micro-pump at speed of 30 μg/min to 66.7 μg/min.The changes of systolic blood pressure (SBP),diastolic blood pressure(DBP),heart rate(HR) and adverse reactions were recorded before administration and 60 minutes after infusion.Results:The two groups were statistically different concerning the changes of SPB,DPB and HR at 60 minute after administration(P <0.05),and the SBP and DBP were decreased,and HR was increased within the group by 60 minute after infusion(P<0.01).Adverse reactions were less in the two groups of pa-tients,and primarily associated with headaches and sinus tachycardia.Conclusion:Nitroglycerin is superior to nicardipine in therapy of renal hypertensive emergency by intravenous infusion via micro-pump,and there is no adverse reaction observed,suggesting that this drug is worthy of wider clinical recom-mendation.