陕西中医
陝西中醫
협서중의
Shaanxi Journal of Traditional Chinese Medicine
2015年
10期
1433-1434
,共2页
三乌丸%急性毒性%半数致死量%动物 ,实验%小鼠
三烏汍%急性毒性%半數緻死量%動物 ,實驗%小鼠
삼오환%급성독성%반수치사량%동물 ,실험%소서
Sanwu pill%Acute toxicity%Median lethal dose%Animal,experiment%Mice
目的:观测小鼠分别口服大剂量三乌丸的半数致死量,以评价其安全性。方法:在死亡率0%(Dn)和100%(Dm )范围内确定5个给药剂量,每个剂量组用10只小鼠,观察14d ,用Bliss 法计算出半数致死量(LD50)等数据。结果:三乌丸小鼠灌胃给药测得LD50为5.12±0.4232g /kg。结论:三乌丸的治疗量没有发生任何毒性反应,是非常安全可行的。
目的:觀測小鼠分彆口服大劑量三烏汍的半數緻死量,以評價其安全性。方法:在死亡率0%(Dn)和100%(Dm )範圍內確定5箇給藥劑量,每箇劑量組用10隻小鼠,觀察14d ,用Bliss 法計算齣半數緻死量(LD50)等數據。結果:三烏汍小鼠灌胃給藥測得LD50為5.12±0.4232g /kg。結論:三烏汍的治療量沒有髮生任何毒性反應,是非常安全可行的。
목적:관측소서분별구복대제량삼오환적반수치사량,이평개기안전성。방법:재사망솔0%(Dn)화100%(Dm )범위내학정5개급약제량,매개제량조용10지소서,관찰14d ,용Bliss 법계산출반수치사량(LD50)등수거。결과:삼오환소서관위급약측득LD50위5.12±0.4232g /kg。결론:삼오환적치료량몰유발생임하독성반응,시비상안전가행적。
Objective:Observed the median lethal dose of San‐wu pill in mouse ,to evaluate its safety .Methods :In the mortality rate of 0% (Dn) and 100% (Dm ) within the scope of five give medicine doses were determined ,each dose group including 10 mouses ,observing 14 days ,by Bliss method to calculate the median lethal dose (LD50) and other data .Results :The dose of Sanwu pill to fill the stomach to measure LD50 of mouse was 5 .12 ± 0 .4232 g/kg .Conclu‐sions :The treatment dose of Sanwu pill was without any toxic effects ,and it is very safe and feasible .