CAJ | 학술논문

目的：比较蔗糖铁注射液不同给药频次治疗缺铁性贫血患者的临床疗效。方法选取450例住院缺铁性贫血（ IDA）患者，随机分为2组，其中Ⅰ组220例，静脉滴注蔗糖铁注射液，100 mg／次，1次／d；Ⅱ组230例，静脉滴注蔗糖铁注射液，100 mg／次，隔天1次，比较治疗前后患者血红蛋白（ Hb）、网织红细胞（ Ret）、红细胞压积（ HCT）等的变化，观察两组疗效、住院时间及不良反应发生率。结果治疗1周后，Ⅰ组总有效率明显高于Ⅱ组（P＜0．05），治疗2周后两组总有效率比较，差异无统计学意义（ P＞0．05）；与治疗前比较，治疗后Hb、HCT、Ret明显升高（ P＜0．05）；治疗后1周组间比较，Ⅰ组Hb、HCT、Ret上升程度明显高于Ⅱ组（ P＜0．05），治疗后2周两组Hb、HCT、Ret上升程度比较，差异无统计学意义（ P＞0．05）；I组平均住院时间明显低于II组（ P＜0．05）；两组不良反应发生率比较，差异无统计学意义（ P＞0．05）。结论蔗糖铁注射液每次静脉给药100 mg ，1次／d治疗IDA安全性高，明显缩短住院时间，减少住院费用，是住院IDA患者比较可取及安全的治疗方案。
목적：비교자당철주사액불동급약빈차치료결철성빈혈환자적림상료효。방법선취450례주원결철성빈혈（ IDA）환자，수궤분위2조，기중Ⅰ조220례，정맥적주자당철주사액，100 mg／차，1차／d；Ⅱ조230례，정맥적주자당철주사액，100 mg／차，격천1차，비교치료전후환자혈홍단백（ Hb）、망직홍세포（ Ret）、홍세포압적（ HCT）등적변화，관찰량조료효、주원시간급불량반응발생솔。결과치료1주후，Ⅰ조총유효솔명현고우Ⅱ조（P＜0．05），치료2주후량조총유효솔비교，차이무통계학의의（ P＞0．05）；여치료전비교，치료후Hb、HCT、Ret명현승고（ P＜0．05）；치료후1주조간비교，Ⅰ조Hb、HCT、Ret상승정도명현고우Ⅱ조（ P＜0．05），치료후2주량조Hb、HCT、Ret상승정도비교，차이무통계학의의（ P＞0．05）；I조평균주원시간명현저우II조（ P＜0．05）；량조불량반응발생솔비교，차이무통계학의의（ P＞0．05）。결론자당철주사액매차정맥급약100 mg ，1차／d치료IDA안전성고，명현축단주원시간，감소주원비용，시주원IDA환자비교가취급안전적치료방안。
Objective To compare the cIinicaI effect of iron deficiency anemia with sucrose iron injection with different frequency of drug use.Methods SeIect 450 cases of hospitaIized patients with iron deficiency anemia ( IDA),randomIy divided into 2 groups,incIuding Ⅰ group 220 ex-ampIes,sucrose iron injection intravenous drip,100 mg/times,one times/d;Ⅱgroup 230 exam-pIes,sucrose iron injection intravenous drip,100 mg/times,every other day one times,before and after treatment were compared hemogIobin (Hb),reticuIocyte (Ret),red bIood ceIIs de-posited ( HCT) ,and other changes,to observe the curative effect of the two groups, Iength of hospitaI stay and the incidence of adverse reactions.Results 1 week after treatment,the totaI ef-fective Ⅰgroup was obviousIy higher than that of Ⅱ group (P<0.05),after 2 weeks of treat-ment two group totaI effective rate,there was no statisticaIIy significant difference ( P>0.05);Compared with before treatment,Hb,HCT,Ret increased obviousIy after treatment ( P<0.05);1 week after treatment compared between groups,Hb,Hct and Ret rising degree in groupⅠwas significantIy higher than those in groupⅡ( P<0.05) ,after 2 weeks of treatmen,two groups of Hb,HCT,Ret rising degree of comparison, there was no statisticaIIy significant difference ( P>0.05);Ⅰgroup set the average Iength of hospitaI stay was Iower than that in group Ⅱ ( P<0.05);The incidence of adverse reactions in the two groups was not statisticaIIy significant ( P>0.05).Conclusion Sucrose iron injection intravenousIy administered 100 mg each time,1 times /d in the treatment of IDA for its high security,significantIy shorten the Iength of hospitaI stay and reduce the cost of hospitaIization,is a reIativeIy desirabIe and safe treatment pIan for hospi-taIized patients with IDA.