中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
Chinese Journal of Hepatobiliary Surgery
2015年
9期
604-607
,共4页
叶佩燕%陆云飞%徐庆年%陈晓蓉%杨宗国
葉珮燕%陸雲飛%徐慶年%陳曉蓉%楊宗國
협패연%륙운비%서경년%진효용%양종국
长链非编码RNA%肝细胞癌%临床病理学特征
長鏈非編碼RNA%肝細胞癌%臨床病理學特徵
장련비편마RNA%간세포암%림상병이학특정
Long non-coding RNA%Hepatocellular carcinoma%Clinico-pathological characteristics
目的 分析肝细胞癌肿瘤(HCC)组织中长链非编码RNA(LncRNA)与临床病理学特征的相关性.方法 利用GEO微阵列肝细胞癌基因数据集,分析8种与肝脏疾病相关的LncRNA与HCC临床病理学的相关性以及LncRNA对HCC临床病理学特征的影响.结果 H19在癌旁组织中高表达(P＜0.05),MEG3、HOXA13、KCNQ1OT1在HCC肿瘤组织中表达水平明显高于癌旁组织(P＜0.05).HCC肿瘤组织中HULC与AJCC分级、BCLC分级、肿瘤大小呈负相关(P＜0.05),UCA1表达与BCLC分级呈正相关(r=0.135,P＜0.05).Logistic单因素与多因素分析显示,UCA1是HCC肝内转移的危险因素(OR=6.054,95％ CI=1.429 ～ 25.642,P＜0.05).相反,肿瘤组织中HULC可能为HCC肿瘤大小的抑制性保护因子(OR=0.805,95％ CI=0.678 ～0.956,P＜0.05).结论 HULC为抑制HCC发展的保护性因子,UCA1高表达可能为促进HCC发展的危险因素.
目的 分析肝細胞癌腫瘤(HCC)組織中長鏈非編碼RNA(LncRNA)與臨床病理學特徵的相關性.方法 利用GEO微陣列肝細胞癌基因數據集,分析8種與肝髒疾病相關的LncRNA與HCC臨床病理學的相關性以及LncRNA對HCC臨床病理學特徵的影響.結果 H19在癌徬組織中高錶達(P＜0.05),MEG3、HOXA13、KCNQ1OT1在HCC腫瘤組織中錶達水平明顯高于癌徬組織(P＜0.05).HCC腫瘤組織中HULC與AJCC分級、BCLC分級、腫瘤大小呈負相關(P＜0.05),UCA1錶達與BCLC分級呈正相關(r=0.135,P＜0.05).Logistic單因素與多因素分析顯示,UCA1是HCC肝內轉移的危險因素(OR=6.054,95％ CI=1.429 ～ 25.642,P＜0.05).相反,腫瘤組織中HULC可能為HCC腫瘤大小的抑製性保護因子(OR=0.805,95％ CI=0.678 ～0.956,P＜0.05).結論 HULC為抑製HCC髮展的保護性因子,UCA1高錶達可能為促進HCC髮展的危險因素.
목적 분석간세포암종류(HCC)조직중장련비편마RNA(LncRNA)여림상병이학특정적상관성.방법 이용GEO미진렬간세포암기인수거집,분석8충여간장질병상관적LncRNA여HCC림상병이학적상관성이급LncRNA대HCC림상병이학특정적영향.결과 H19재암방조직중고표체(P＜0.05),MEG3、HOXA13、KCNQ1OT1재HCC종류조직중표체수평명현고우암방조직(P＜0.05).HCC종류조직중HULC여AJCC분급、BCLC분급、종류대소정부상관(P＜0.05),UCA1표체여BCLC분급정정상관(r=0.135,P＜0.05).Logistic단인소여다인소분석현시,UCA1시HCC간내전이적위험인소(OR=6.054,95％ CI=1.429 ～ 25.642,P＜0.05).상반,종류조직중HULC가능위HCC종류대소적억제성보호인자(OR=0.805,95％ CI=0.678 ～0.956,P＜0.05).결론 HULC위억제HCC발전적보호성인자,UCA1고표체가능위촉진HCC발전적위험인소.
Objective To evaluate the relationship between long non-coding RNAs (LncRNA) in tumor tissues and clinico-pathological features of hepatocllular carcinoma (HCC).Methods Using hepatocellular carcinoma gene database GSE36376,we conducted a study on eight LncRNAs which are associated with liver diseases and analyzed the correlation between these LncRNAs and HCC clinico-pathological characteristics.We also evaluated the potential effect of LncRNAs on HCC development.Results H19 was overexpressed in non-tumorous tissues of HCC (P ＜ 0.05),while MEG3,HOXA13,KCNQ1OT1 were all upregulated in tumorous tissues (all P ＜ 0.05).HULC level in HCC tumorous tissues was negatively correlated with AJCC staging,BCLC staging and tumor size (all P ＜ 0.05).UCA1 was positively correlated with BCLC staging (r =0.135,P ＜ 0.05).Univariate analysis and multivariate logistic analyses showed that UCA1 was a risk factor of intrahepatic metastasis of HCC (OR =6.054,95％ CI =1.429 ～ 25.642,P ＜ 0.05); in contrast,HULC overexpression in tumorous tissues played a positive role in HCC tumor size (OR=0.805,95％CI=0.678 ～0.956,P＜0.05).Conclusion HULC in tumorous tissues suppressed HCC proliferation,while UCA1 was a risk factor of HCC aggressiveness.
