中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
9期
935-938
,共4页
李辉%刘兵%赵迎%沈月莉%林颖%季福绥%孙福成%许锋%何青
李輝%劉兵%趙迎%瀋月莉%林穎%季福綏%孫福成%許鋒%何青
리휘%류병%조영%침월리%림영%계복수%손복성%허봉%하청
肾病%冠状血管造影术%肾小球滤过率%造影剂
腎病%冠狀血管造影術%腎小毬濾過率%造影劑
신병%관상혈관조영술%신소구려과솔%조영제
Nephrosis%Coronary angiography%Glomerular filtration rate%Contrastmedia
目的 了解老年患者在冠状动脉造影术后对比剂肾病(CIN)的发生率和主要危险因素. 方法 回顾分析2011年1月至2012年12月在北京医院心内科行冠状动脉造影和(或)介入治疗的老年患者1 627例,术后发生CIN患者45例为CIN组,非CIN组1 582例,分析两组患者的基线资料,应用多因素Logistic回归分析确定发病危险因素. 结果 CIN发生率为2.8％(45/1 627).非CIN组和CIN组患者年龄＞70岁[56.9％(900例)比80.0％(36例)]、估算的肾小球滤过率＜60ml·min-1·1.73 m-2[28.9％(457例)和53.3％(24例)]、使用利尿剂[15.5％(245例)比31.1％(14例)]、低收缩压＜100 mmHg[1 mmHg=0.133 kPa,5.4％(85例)和6.7％(3例)]比较,差异有统计学意义(P＜0.05或P＜0.01).以年龄＞70岁、估算的肾小球滤过率＜60 ml· min-1·1.73m-2、使用利尿剂、低收缩压为变量行多因素Logistic回归分析,结果 显示年龄＞70岁、估算的肾小球滤过率＜60 ml· min-1·1.73 m-2、使用利尿剂是发生CIN的独立危险因素(OR值分别为2.21、1.93和1.97,均P＜0.05). 结论老年患者是发生CIN的高危人群,主要的危险因素为年龄、基础肾脏功能和应用利尿剂.
目的 瞭解老年患者在冠狀動脈造影術後對比劑腎病(CIN)的髮生率和主要危險因素. 方法 迴顧分析2011年1月至2012年12月在北京醫院心內科行冠狀動脈造影和(或)介入治療的老年患者1 627例,術後髮生CIN患者45例為CIN組,非CIN組1 582例,分析兩組患者的基線資料,應用多因素Logistic迴歸分析確定髮病危險因素. 結果 CIN髮生率為2.8％(45/1 627).非CIN組和CIN組患者年齡＞70歲[56.9％(900例)比80.0％(36例)]、估算的腎小毬濾過率＜60ml·min-1·1.73 m-2[28.9％(457例)和53.3％(24例)]、使用利尿劑[15.5％(245例)比31.1％(14例)]、低收縮壓＜100 mmHg[1 mmHg=0.133 kPa,5.4％(85例)和6.7％(3例)]比較,差異有統計學意義(P＜0.05或P＜0.01).以年齡＞70歲、估算的腎小毬濾過率＜60 ml· min-1·1.73m-2、使用利尿劑、低收縮壓為變量行多因素Logistic迴歸分析,結果 顯示年齡＞70歲、估算的腎小毬濾過率＜60 ml· min-1·1.73 m-2、使用利尿劑是髮生CIN的獨立危險因素(OR值分彆為2.21、1.93和1.97,均P＜0.05). 結論老年患者是髮生CIN的高危人群,主要的危險因素為年齡、基礎腎髒功能和應用利尿劑.
목적 료해노년환자재관상동맥조영술후대비제신병(CIN)적발생솔화주요위험인소. 방법 회고분석2011년1월지2012년12월재북경의원심내과행관상동맥조영화(혹)개입치료적노년환자1 627례,술후발생CIN환자45례위CIN조,비CIN조1 582례,분석량조환자적기선자료,응용다인소Logistic회귀분석학정발병위험인소. 결과 CIN발생솔위2.8％(45/1 627).비CIN조화CIN조환자년령＞70세[56.9％(900례)비80.0％(36례)]、고산적신소구려과솔＜60ml·min-1·1.73 m-2[28.9％(457례)화53.3％(24례)]、사용이뇨제[15.5％(245례)비31.1％(14례)]、저수축압＜100 mmHg[1 mmHg=0.133 kPa,5.4％(85례)화6.7％(3례)]비교,차이유통계학의의(P＜0.05혹P＜0.01).이년령＞70세、고산적신소구려과솔＜60 ml· min-1·1.73m-2、사용이뇨제、저수축압위변량행다인소Logistic회귀분석,결과 현시년령＞70세、고산적신소구려과솔＜60 ml· min-1·1.73 m-2、사용이뇨제시발생CIN적독립위험인소(OR치분별위2.21、1.93화1.97,균P＜0.05). 결론노년환자시발생CIN적고위인군,주요적위험인소위년령、기출신장공능화응용이뇨제.
Objective To investigate the morbidity of contrast-induced nephropathy (CIN) after coronary angiography in elderly people and its major risk factors.Methods We conducted a retrospective observational study to analyze the patients who underwent coronary angiography and/or angioplasty in Beijing Hospital from January 2011 to December 2012.1 627 patients were enrolled in this study and divided into CIN group (n=45) and non-CIN group (1 582).Clinical baseline data in the two groups were analyzed,and the risk factors were determined by multivariate Logistic regression analysis.Results The incidence of CIN was 2.8％ (45/1 627).Between the two groups with or without CIN,there were differences in age＞70 years,estimated glomerular filtration rate (eGFR) ＜ 60 ml · min-1 · 1.73 m-2,use of diuretic,low blood pressure ＜100 mmHg [56.9％ (900 cases) vs.80.0％ (36 cases),28.9％ (457 cases) vs.53.3％ (24 cases),15.5％ (245 cases) vs.31.1％ (14 cases),5.4％ (85 cases) vs.6.7％ (3 cases),respectively,P＜0.05 or 0.01].Multivariate logistic regression analysis showed that age＞70 years,eGFR ＜60 ml · min-1 · 1.73 m-2,and use of diuretic were the independent risk factors for CIN (OR =2.21,1.93,1.97,respectively,all P＜0.05).Conclusions The elderly people have the high risk for CIN after coronary angiography,and the major risk factors include age,basal renal function and use of diuretic.
