中国药物与临床
中國藥物與臨床
중국약물여림상
Chinese Remedies & Clinics
2015年
9期
1232-1233
,共2页
郝志英%李亚冬%张瑞学%李青山
郝誌英%李亞鼕%張瑞學%李青山
학지영%리아동%장서학%리청산
抗肿瘤联合化疗方案%宫颈肿瘤%治疗结果
抗腫瘤聯閤化療方案%宮頸腫瘤%治療結果
항종류연합화료방안%궁경종류%치료결과
Antineoplastic combined chemotherapy protocols%Cervix neoplasms%Treatment outcome
目的 探究顺铂分别与多西它赛和紫杉醇联合对晚期宫颈癌的临床疗效.方法 选取我院收治的80例局部晚期宫颈癌患者,采取随机数字表法将其分成A、B组,每组40例.A组患者采用多西它赛75 mg/m2+顺铂50 mg/m2,B组患者采用紫杉醇60 mg/m2+顺铂50 mg/m2,分别化疗l~2个疗程,化疗间隔时间均为21 d,观察与比较2组患者经不同治疗方法后的临床疗效及不良反应等情况.结果 A、B组患者经不同用药方式后,疗效差异无统计学意义(P>0.05).B组患者出现不良反应的例数明显高于A组患者,差异有统计学意义(P<0.05).结论 多西它赛75 mg/m2联合顺铂50 mg/m2对晚期宫颈癌临床作用显著,且不良反应较少,安全性高.
目的 探究順鉑分彆與多西它賽和紫杉醇聯閤對晚期宮頸癌的臨床療效.方法 選取我院收治的80例跼部晚期宮頸癌患者,採取隨機數字錶法將其分成A、B組,每組40例.A組患者採用多西它賽75 mg/m2+順鉑50 mg/m2,B組患者採用紫杉醇60 mg/m2+順鉑50 mg/m2,分彆化療l~2箇療程,化療間隔時間均為21 d,觀察與比較2組患者經不同治療方法後的臨床療效及不良反應等情況.結果 A、B組患者經不同用藥方式後,療效差異無統計學意義(P>0.05).B組患者齣現不良反應的例數明顯高于A組患者,差異有統計學意義(P<0.05).結論 多西它賽75 mg/m2聯閤順鉑50 mg/m2對晚期宮頸癌臨床作用顯著,且不良反應較少,安全性高.
목적 탐구순박분별여다서타새화자삼순연합대만기궁경암적림상료효.방법 선취아원수치적80례국부만기궁경암환자,채취수궤수자표법장기분성A、B조,매조40례.A조환자채용다서타새75 mg/m2+순박50 mg/m2,B조환자채용자삼순60 mg/m2+순박50 mg/m2,분별화료l~2개료정,화료간격시간균위21 d,관찰여비교2조환자경불동치료방법후적림상료효급불량반응등정황.결과 A、B조환자경불동용약방식후,료효차이무통계학의의(P>0.05).B조환자출현불량반응적례수명현고우A조환자,차이유통계학의의(P<0.05).결론 다서타새75 mg/m2연합순박50 mg/m2대만기궁경암림상작용현저,차불량반응교소,안전성고.
Objective To investigate the clinical effects of Cisplatin combined with Docetaxel versus Cy-clophosphamide on advanced cervical cancer. Methods Eighty patients with locally advanced cervical cancer hospi-talized in our hospital were included as the subjects in the study, and were divided into groups A and B randomly ( n=40 each). Group A received Docetaxel 75 mg/m2 and Cisplatin 50 mg/m2, while group B received Paclitaxel 60 mg/m2 and Cisplatin 50 mg/m2, with 1 to 2 courses of chemotherapies and an interval of 21 d. The clinical effects and ad-verse reactions of the two chemotherapies were determined and compared between the two groups of patients. Results There was no statistically significant difference in the effect between groups A and B after received different medica-tion (P>0.05). The number of patients with adverse reactions in group B was significantly higher than that in group A, with statistically significant difference (P<0.05). Conclusion Docetaxel 75 mg/m2 and Cisplatin 50 mg/m2 have sig-nificantly clinical effects on advanced cervical cancer, with less adverse reactions and high safety.
