CAJ | 학술논문

目的观察并评估人类免疫缺陷病毒(HIV)阳性的肿瘤患者放射治疗的急性放射性反应.方法回顾性分析云南省肿瘤医院2008年2月至2013年12月收治的14例HIV阳性恶性肿瘤患者,在接受放射治疗期间和治疗后1个月的放射不良反应.急性反应依据照射部位分类,参照不良事件通用术语标准(CTCAE 3.0版)分级.结果 7例患者放疗中断或延期,2例未完成放疗.皮肤、黏膜反应多见,如皮炎、咽炎、腹泻.8例患者放疗期间出现3级急性放射反应,其中,6例患者有3级皮肤反应,2例有3级黏膜反应.结论放射治疗对HIV阳性的肿瘤患者是一种有效的治疗手段,但会引发重的急性放射反应.
목적 관찰병평고인류면역결함병독(HIV)양성적종류환자방사치료적급성방사성반응.방법 회고성분석운남성종류의원2008년2월지2013년12월수치적14례HIV양성악성종류환자,재접수방사치료기간화치료후1개월적방사불량반응.급성반응의거조사부위분류,삼조불량사건통용술어표준(CTCAE 3.0판)분급.결과 7례환자방료중단혹연기,2례미완성방료.피부、점막반응다견,여피염、인염、복사.8례환자방료기간출현3급급성방사반응,기중,6례환자유3급피부반응,2례유3급점막반응.결론 방사치료대HIV양성적종류환자시일충유효적치료수단,단회인발중적급성방사반응.
Objective To observe and evaluate acute toxicities in a series of human immunodeficiency virus (HIV)-positive cancer patients receiving radiation therapy.Methods The study retrospectively reviewed the acute radiation reaction of radiation therapy of 14 HIV seropositive patients diagnosed with carcinoma between Feb 2008 and Dec 2013 at the Yunnan Tumor Hospital during the radiotherapy period and 1 month following treatment.Acute adverse effects were classified according to the site of radiation therapy and analyzed using the Common Terminology Criteria for Adverse Events (CTCAE) version 3.0.Results Seven patients experienced interruptions or delays in treatment,and 2 stopped treatment entirely.The most common acute adverse effects were skin reactions and mucous membrane reactions,including dermatitis,stomatitis or diarrhea.Eight patients had grade 3 acute adverse effects,including 6 patients with grade 3 skin reactions and 2 patients with grade 3 mucosa reactions.Conclusions Radiotherapy is an effective treatment for HIV positive patients with tumors,however it frequently induced severe acute radiation responses.