中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
Journal of Endocrine Surgery
2015年
4期
302-304,308
,共4页
终末期肾功能衰竭%甲状腺%结节
終末期腎功能衰竭%甲狀腺%結節
종말기신공능쇠갈%갑상선%결절
End-stage renal disease%Thyroid%Nodule
目的 观察终末期肾功能衰竭(end-stage renal failure,ESRF)透析患者的甲状腺功能改变和结节发病率.方法 回顾性分析2012年1月至2012年4月50例ESRF住院透析治疗患者,对照组为55例连续性门诊患者,采用高频超声检查测量甲状腺大小并计算体积,观察甲状腺回声改变及有无结节存在,同时行甲状腺激素、甲状旁腺激素、肾功能等相关血液学检测.结果 ESRF患者平均三碘甲状腺原氨酸(T3)(1.05±0.23)mg/ml,游离三碘甲状腺原氨酸(FT3)(33.1 ±0.41)pg/ml均低于对照组(1.14±0.25) pg/ml和(3.31 ±0.57) pg/ml,差异有统计学意义(P=0.038和0.029);前组血清促甲状腺激素(TSH)高于对照组(3.29±1.77 mIU/L vs 2.37±0.67 mIU/L),差异有统计学意义(P=0.001);超声诊断ESRF组32％ (16/50)合并甲状腺结节,高于对照组3.6％(2/55),差异有统计学意义(P ＜0.001);ESRF合并甲状腺结节患者平均年龄高于未合并甲状腺结节患者(52.94±14.21 vs 42.32±11.37),差异有统计学意义(P=0.006).结论 ESRF患者中甲状腺功能改变和甲状腺结节发生率均显著性增加,超声有利于临床精确评价.
目的 觀察終末期腎功能衰竭(end-stage renal failure,ESRF)透析患者的甲狀腺功能改變和結節髮病率.方法 迴顧性分析2012年1月至2012年4月50例ESRF住院透析治療患者,對照組為55例連續性門診患者,採用高頻超聲檢查測量甲狀腺大小併計算體積,觀察甲狀腺迴聲改變及有無結節存在,同時行甲狀腺激素、甲狀徬腺激素、腎功能等相關血液學檢測.結果 ESRF患者平均三碘甲狀腺原氨痠(T3)(1.05±0.23)mg/ml,遊離三碘甲狀腺原氨痠(FT3)(33.1 ±0.41)pg/ml均低于對照組(1.14±0.25) pg/ml和(3.31 ±0.57) pg/ml,差異有統計學意義(P=0.038和0.029);前組血清促甲狀腺激素(TSH)高于對照組(3.29±1.77 mIU/L vs 2.37±0.67 mIU/L),差異有統計學意義(P=0.001);超聲診斷ESRF組32％ (16/50)閤併甲狀腺結節,高于對照組3.6％(2/55),差異有統計學意義(P ＜0.001);ESRF閤併甲狀腺結節患者平均年齡高于未閤併甲狀腺結節患者(52.94±14.21 vs 42.32±11.37),差異有統計學意義(P=0.006).結論 ESRF患者中甲狀腺功能改變和甲狀腺結節髮生率均顯著性增加,超聲有利于臨床精確評價.
목적 관찰종말기신공능쇠갈(end-stage renal failure,ESRF)투석환자적갑상선공능개변화결절발병솔.방법 회고성분석2012년1월지2012년4월50례ESRF주원투석치료환자,대조조위55례련속성문진환자,채용고빈초성검사측량갑상선대소병계산체적,관찰갑상선회성개변급유무결절존재,동시행갑상선격소、갑상방선격소、신공능등상관혈액학검측.결과 ESRF환자평균삼전갑상선원안산(T3)(1.05±0.23)mg/ml,유리삼전갑상선원안산(FT3)(33.1 ±0.41)pg/ml균저우대조조(1.14±0.25) pg/ml화(3.31 ±0.57) pg/ml,차이유통계학의의(P=0.038화0.029);전조혈청촉갑상선격소(TSH)고우대조조(3.29±1.77 mIU/L vs 2.37±0.67 mIU/L),차이유통계학의의(P=0.001);초성진단ESRF조32％ (16/50)합병갑상선결절,고우대조조3.6％(2/55),차이유통계학의의(P ＜0.001);ESRF합병갑상선결절환자평균년령고우미합병갑상선결절환자(52.94±14.21 vs 42.32±11.37),차이유통계학의의(P=0.006).결론 ESRF환자중갑상선공능개변화갑상선결절발생솔균현저성증가,초성유리우림상정학평개.
Objective To investigate the thyroid structure changes using a high-frequency sonography and thyroid dysfunction in end-stage renal failure(ESRF) patients.Methods From Jan.2012 to Apr.2012,50 ESRF patients and 55 consecutive outpatients(nonthyroid diseases visitors)as normal controls were included in the study.The size of thyroid gland was measured with ultrasonography and the volume was calculated.The internal echo changes and status of nodules were observed.Measurement such as thyroid hormones,parathyroid hormones and renal function were performed all patients.Results The serum level of T3,FT3 in ESRF patients were significantly lower than those of the control patients(1.05 ±0.23 mg/ml vs 1.14 ±0.25 pg/ml,P =0.038;3.1 ± 0.41 pg/ml vs 3.31 ±0.57 pg/ml,P =0.029),while the serum level of TSH was significandy higher in ESRF group than in the control group (3.29 ± 1.77 mIU/L vs 2.37 ± 0.67 mIU/L,P =0.001).Ultrasonography showed that 32％ (16/50) of ESRF patients and 3.6％ (2/55) of the controls had thyroid goiter (P ＜ 0.001).Compared to ESRF patients without nodules,the average age was significantly higher in patients with nodules (52.94 ± 14.21 vs 42.32 ± 11.37,P =0.006).Conclusion ESRF patients tend to have a higher incidence of alteration of thyroid function and nodular goiter which can be effectively assessed by ultrasonography.
