海岸生命医学杂志（英文版）
海岸生命醫學雜誌（英文版）
해안생명의학잡지（영문판）
Journal of Coastal Life medicine
2014年
11期
907-914
,共8页
Montelukast sodium%Gelatin%Hydroxy propyl methyl cellulose%Poly vinyl pyrrolidone%Buccal film%In-vitro release
Objective: To formulate and evaluate anti-asthmatic drug montelukast in mucoadhesive buccal patches. <br> Methods:Buccal patches were formulated by using different hydrophilic polymers by solvent casting technique. Buccal patches were evaluated by seven physical appearances, in addition toin vitro drug release study. <br> Results: All patches were uniform and translucent, and had smooth surface. In vitro release studies were conducted for montelukast buccal patches proved that release in the range of 75.26%-92.30% in 8 h. Emission of montelukast from all patches simulated zero order and diffusion mechanism. Finally it can be concluded that F3, F15 and F16 are the best formulation. <br> Conclusions: The investigation concluded that patch of 5 mg of montelukast sodium were formulated by using sodium alginate with sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose K100M with sodium carboxy methyl cellulose, and hydroxy propyl methyl cellulose K100M with sodium alginate (F3, F15 and F16 formulations) were the best formulations.
