中国医科大学学报
中國醫科大學學報
중국의과대학학보
Journal of China Medical University
2015年
9期
829-832
,共4页
表皮生长因子受体%HER?2/neu%蛋白%胃癌%表达%预后
錶皮生長因子受體%HER?2/neu%蛋白%胃癌%錶達%預後
표피생장인자수체%HER?2/neu%단백%위암%표체%예후
epidermal growth factor receptor%HER?2/neu%protein%gastric cancer%expression%prognosis
目的 探讨表皮生长因子受体(EGFR)、HER?2/neu蛋白在胃癌中的表达及其与预后的关系.方法 回顾性分析2006年11月至2013年11月我院收治的90例胃癌患者(观察组)的临床资料,另选取正常胃组织50例作为对照组.观察2组EGFR、HER?2/neu蛋白的表达情况,分析胃癌组织中EGFR、HER?2/neu蛋白表达和临床病理特征的关系.结果 观察组EGFR、HER?2/neu蛋白表达阳性率高于对照组,差异均有统计学意义(P<0.05).EGFR、HER?2/neu蛋白表达和胃癌患者的性别、年龄、肿瘤部位、肿瘤直径无相关性(P>0.05),而与胃癌分化程度、临床分期、浸润深度、淋巴结转移、远处转移密切相关,差异均有统计学意义(P<0.05).EGFR与HER?2/neu表达呈正相关.结论 EGFR、HER?2/neu蛋白的表达与胃癌的发生发展密切相关.EGFR与HER?2/neu的表达呈正相关.
目的 探討錶皮生長因子受體(EGFR)、HER?2/neu蛋白在胃癌中的錶達及其與預後的關繫.方法 迴顧性分析2006年11月至2013年11月我院收治的90例胃癌患者(觀察組)的臨床資料,另選取正常胃組織50例作為對照組.觀察2組EGFR、HER?2/neu蛋白的錶達情況,分析胃癌組織中EGFR、HER?2/neu蛋白錶達和臨床病理特徵的關繫.結果 觀察組EGFR、HER?2/neu蛋白錶達暘性率高于對照組,差異均有統計學意義(P<0.05).EGFR、HER?2/neu蛋白錶達和胃癌患者的性彆、年齡、腫瘤部位、腫瘤直徑無相關性(P>0.05),而與胃癌分化程度、臨床分期、浸潤深度、淋巴結轉移、遠處轉移密切相關,差異均有統計學意義(P<0.05).EGFR與HER?2/neu錶達呈正相關.結論 EGFR、HER?2/neu蛋白的錶達與胃癌的髮生髮展密切相關.EGFR與HER?2/neu的錶達呈正相關.
목적 탐토표피생장인자수체(EGFR)、HER?2/neu단백재위암중적표체급기여예후적관계.방법 회고성분석2006년11월지2013년11월아원수치적90례위암환자(관찰조)적림상자료,령선취정상위조직50례작위대조조.관찰2조EGFR、HER?2/neu단백적표체정황,분석위암조직중EGFR、HER?2/neu단백표체화림상병리특정적관계.결과 관찰조EGFR、HER?2/neu단백표체양성솔고우대조조,차이균유통계학의의(P<0.05).EGFR、HER?2/neu단백표체화위암환자적성별、년령、종류부위、종류직경무상관성(P>0.05),이여위암분화정도、림상분기、침윤심도、림파결전이、원처전이밀절상관,차이균유통계학의의(P<0.05).EGFR여HER?2/neu표체정정상관.결론 EGFR、HER?2/neu단백적표체여위암적발생발전밀절상관.EGFR여HER?2/neu적표체정정상관.
Objective To study the expressions of EGFR and HER?2/neu proteins in gastric carcinoma and the conditions of prognosis. Methods The clinical data of 90 gastric cancer patients during November 2006 to November 2013 were chosen as the observation group,and 50 cases of nor?mal gastric tissues were chosen as the control group. The expressions of EGFR and HER?2/neu proteins in the two groups were measured by immuno?histochemical staining to analyze the relationship of their expression with clinical features. Results The positive rate of EGFR and HER?2/neu ex?pressions in the observation group was higher than the control group,with statistical significance(P<0.05). The expressions of EGFR and HER?2/neu proteins were closely related with differentiation,clinical stages,mucosa invasion depth,lymphatic metastasis,distant metastasis of gastric can?cer,with statistical significance(P<0.05),however,no relations were detected with gender,age,tumor size and tumor site(P>0.05). The expres?sion of EGFR showed a positive correlation with HER?2/neu. Conclusion There was a close relationship of EGFR and HER?2/neu expressions with the onset and progression of gastric cancer. The expression of EGFR showed a positive correlation with HER?2/neu.
