CAJ | 학술논문

目的检测乳腺癌患者手术治疗前后血清中可溶性E?钙黏连蛋白(EC)的表达并探讨其临床意义.方法采用酶联免疫吸附法(ELISA)检测42例乳腺癌患者手术前后、18例乳腺良性病变患者手术前后以及30例健康人血清中可溶性EC的表达水平.并分析乳腺癌手术前后血清中可溶性EC的水平变化及与其临床病理特征的关系.结果乳腺癌患者术前血清可溶性EC较乳腺良性病变患者和健康人显著升高;乳腺癌患者术后血清可溶性EC水平较术前明显下降;高分期以及伴有淋巴结转移的乳腺癌患者的血清可溶性EC明显高于低分期及无淋巴结转移患者(P<0.05).结论乳腺癌患者血清可溶性EC在手术前后的表达具有特异性并且与肿瘤病理分期以及淋巴结转移显著相关,可能成为乳腺癌患者预后的预测因素.
목적 검측유선암환자수술치료전후혈청중가용성E?개점련단백(EC)적표체병탐토기림상의의.방법 채용매련면역흡부법(ELISA)검측42례유선암환자수술전후、18례유선량성병변환자수술전후이급30례건강인혈청중가용성EC적표체수평.병분석유선암수술전후혈청중가용성EC적수평변화급여기림상병리특정적관계.결과 유선암환자술전혈청가용성EC교유선량성병변환자화건강인현저승고;유선암환자술후혈청가용성EC수평교술전명현하강;고분기이급반유림파결전이적유선암환자적혈청가용성EC명현고우저분기급무림파결전이환자(P<0.05).결론 유선암환자혈청가용성EC재수술전후적표체구유특이성병차여종류병리분기이급림파결전이현저상관,가능성위유선암환자예후적예측인소.
Objective To detect the expression of serum soluble E?cadherin(sEC)before and after operation in breast cancer patients,and to ex?plore its clinical significance. Methods The levels of sEC in 42 patients with breast cancer and 18 patients with benign breast diseases were tested by enzyme?linked immunosorbent assay(ELISA)before and after operation as well as in 30 healthy controls. Its correlation with clinical and patho?logical characteristics was analyzed. Results The levels of sEC in breast cancer patients before operation were significantly higher than patients with benign breast diseases and controls,which declined significantly after operation. Moreover,the levels of sEC in those with high clinical grading and lymphatic metastasis were also higher than in the ones with low grading and negative lymphatic metastasis(P<0.05). Conclusion The levels of sEC in breast cancer patients before operation are specific and closely related with pathological grade and lymphatic metastasis,which may be a pre?dictive factor for prognosis of breast cancer.