国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
International Journal of Epidemiology and Infectious Disease
2015年
4期
256-259
,共4页
机会致病菌感染%马尔尼菲青霉菌%致病性%毒力因子
機會緻病菌感染%馬爾尼菲青黴菌%緻病性%毒力因子
궤회치병균감염%마이니비청매균%치병성%독력인자
Opportunistic infections%Penicillium marneffei%Pathogenicity%Virulence factor
马尔尼菲青霉菌是艾滋病患者常见的机会性致病菌,其致病性与自身毒力因子、致病基因及宿主免疫等有关.随着全基因组测序的完成,基于基因组学和蛋白质组学的新技术不断运用于马尔尼菲青霉菌的致病性研究中.此文就目前马尔尼菲青霉菌致病机制的研究进展进行综述.
馬爾尼菲青黴菌是艾滋病患者常見的機會性緻病菌,其緻病性與自身毒力因子、緻病基因及宿主免疫等有關.隨著全基因組測序的完成,基于基因組學和蛋白質組學的新技術不斷運用于馬爾尼菲青黴菌的緻病性研究中.此文就目前馬爾尼菲青黴菌緻病機製的研究進展進行綜述.
마이니비청매균시애자병환자상견적궤회성치병균,기치병성여자신독력인자、치병기인급숙주면역등유관.수착전기인조측서적완성,기우기인조학화단백질조학적신기술불단운용우마이니비청매균적치병성연구중.차문취목전마이니비청매균치병궤제적연구진전진행종술.
Penicillium marneffei (P.marneffei) is a common opportunistic fungal pathogen in AIDS patients.It has been considered that the pathogenicity of this fungus is related to its virulence factors,pathogenic genes and the immune state of hosts.With the accomplishment of the whole genome sequencing of P.marneffei,new technologies based on genomics and proteomics have been applied to the research on its pathogenicity gradually.This article aims to review the recent advances on the pathogenic mechanism of P.marneffei.
