国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
International Journal of Epidemiology and Infectious Disease
2015年
4期
244-249
,共6页
胡昱%张兵%李倩%陈雅萍%符剑
鬍昱%張兵%李倩%陳雅萍%符劍
호욱%장병%리천%진아평%부검
乳头状瘤病毒疫苗%免疫学效果%免疫程序%系统综述%Meta分析
乳頭狀瘤病毒疫苗%免疫學效果%免疫程序%繫統綜述%Meta分析
유두상류병독역묘%면역학효과%면역정서%계통종술%Meta분석
Papillomavirus vaccines%Immunology effect%Immunization schedules%Systematic review%Meta-analysis
目的 评价人乳头瘤病毒(HPV)疫苗按2剂次免疫程序(2 d)和3剂次免疫程序(3 d)接种后免疫学效果的差异.方法 电子检索美国国家医学图书馆数据库(NCBI)、考克兰协作网图书馆(Cochrane)等数据库,将有关比较按3d和2d接种HPV疫苗免疫学效果的研究纳入分析.通过计算抗体几何平均浓度(GMC)比值来比较按3d和2d接种HPV疫苗后产生针对HPV-16和HPV-18抗体的差异.采用Meta分析合并二价HPV按3d和2d接种后产生的抗体GMC比值.结果 共纳入5篇文献.9～14岁女性按3d与15～26岁女性按2d接种HPV疫苗后针对HPV-16和HPV-18的抗体GMC比值的95％CI上限均未超过非劣效性研究界值2.0;同年龄组女性按3d和2d接种HPV后有部分亚组的抗体GMC比值的95％CI超过2.0;9～14岁女性按2d和3d接种二价HPV疫苗24月后针对HPV-16抗体的GMC比值的95％CI超过2.0.结论 9～14岁女性按2d接种HPV疫苗与15～26岁女性按3d接种HPV产生的免疫学效果相当,在不同随访时间点上未发现采用2d与3d接种HPV疫苗产生的免疫学效果存在差异.
目的 評價人乳頭瘤病毒(HPV)疫苗按2劑次免疫程序(2 d)和3劑次免疫程序(3 d)接種後免疫學效果的差異.方法 電子檢索美國國傢醫學圖書館數據庫(NCBI)、攷剋蘭協作網圖書館(Cochrane)等數據庫,將有關比較按3d和2d接種HPV疫苗免疫學效果的研究納入分析.通過計算抗體幾何平均濃度(GMC)比值來比較按3d和2d接種HPV疫苗後產生針對HPV-16和HPV-18抗體的差異.採用Meta分析閤併二價HPV按3d和2d接種後產生的抗體GMC比值.結果 共納入5篇文獻.9～14歲女性按3d與15～26歲女性按2d接種HPV疫苗後針對HPV-16和HPV-18的抗體GMC比值的95％CI上限均未超過非劣效性研究界值2.0;同年齡組女性按3d和2d接種HPV後有部分亞組的抗體GMC比值的95％CI超過2.0;9～14歲女性按2d和3d接種二價HPV疫苗24月後針對HPV-16抗體的GMC比值的95％CI超過2.0.結論 9～14歲女性按2d接種HPV疫苗與15～26歲女性按3d接種HPV產生的免疫學效果相噹,在不同隨訪時間點上未髮現採用2d與3d接種HPV疫苗產生的免疫學效果存在差異.
목적 평개인유두류병독(HPV)역묘안2제차면역정서(2 d)화3제차면역정서(3 d)접충후면역학효과적차이.방법 전자검색미국국가의학도서관수거고(NCBI)、고극란협작망도서관(Cochrane)등수거고,장유관비교안3d화2d접충HPV역묘면역학효과적연구납입분석.통과계산항체궤하평균농도(GMC)비치래비교안3d화2d접충HPV역묘후산생침대HPV-16화HPV-18항체적차이.채용Meta분석합병이개HPV안3d화2d접충후산생적항체GMC비치.결과 공납입5편문헌.9～14세녀성안3d여15～26세녀성안2d접충HPV역묘후침대HPV-16화HPV-18적항체GMC비치적95％CI상한균미초과비렬효성연구계치2.0;동년령조녀성안3d화2d접충HPV후유부분아조적항체GMC비치적95％CI초과2.0;9～14세녀성안2d화3d접충이개HPV역묘24월후침대HPV-16항체적GMC비치적95％CI초과2.0.결론 9～14세녀성안2d접충HPV역묘여15～26세녀성안3d접충HPV산생적면역학효과상당,재불동수방시간점상미발현채용2d여3d접충HPV역묘산생적면역학효과존재차이.
Objective To evaluate the difference on immunogenicity of 3 doses schedule(3 d) and 2 doses schedule(2 d) of human papillomavirus (HPV) vaccine.Methods By searching database such as "National Center for Biotechnology Information" and "Cochrane Library",the studies of comparing immunogenicity of 3 d and 2 d of HPV vaccination were included.Geometric mean concentrations (GMC) ratios(GMC after 3 d/GMC after 2 d) of HPV-16 and HPV-18 between 3 d and 2 d were calculated.Meta-analysis was adopted to combine pooled GMC ratios (bivalent vaccine) of 3 d and 2 d.Results A total of 5 studies were included.The 95％ CI GMC ratio against HPV-16 and HPV-18 between the 2 d in women aged 15-26 years and the 3 d in women aged 9-14 years did not exceed the non-inferiority (NI) margin of 2.0.The 95％ CI of GMC ratios against HPV-16 and HPV-18 between the 3 d and the 2 d in some equivalent age group exceeded 2.0.The 95％ CI of pooled GMC ratios for the bivalent HPV within women aged 9-14 years between the 3d and the 2 d exceeded 2.0 at 24 months after the last dose.Conclusions The 2 d of women aged 9-14 years has non-inferior immunogenicity compared with the 3 d of women aged 15-26 years.However,there is no difference at various timing of vaccinating HPV by 2d and 3d.
