海岸生命医学杂志（英文版）
海岸生命醫學雜誌（英文版）
해안생명의학잡지（영문판）
Journal of Coastal Life medicine
2014年
9期
721-726
,共6页
Mallotus repandus%α-Amylase%Diabetes mellitus%Hypoglycemic%Oral glucose tolerance test
Objective: To investigate the therapeutic effects of ethyl acetate extract of Mallotus repandus stem in α-amylase inhibitory activity (in vitro) and hypoglycemic activity in normal and glucose induced hyperglycemic rats (in vivo). Methods: Ethyl acetate extract of Mallotus repandus stem was tested for the presence of phytochemical constituents, α-amylase inhibitory activity and hypoglycemic effect in normal rats and glucose induced hyperglycemic rats.Results:Presence of different types of phytochemicals was identified in the extract. The extract has moderate α-amylase inhibitory activity [IC50=(2.038±0.033) mg/mL] as compared to acarbose. The does 1000 mg/kg significantly reduced (P<0.0100) fasting blood glucose level in normal rats. In oral glucose tolerance test, both 1000 and 2000 mg/kg doses showed good hypoglycemic activity (P<0.0001) like glibenclamide in each specific hour after administration. Overall time effect in oral glucose tolerance test was found extremely significant (P<0.0001) with F (3, 48) value=202.4.Conclusions:These findings suggest that this plant may be a potential source for the development of new oral hypoglycemic agent.
