CAJ | 학술논문

目的:比较分析酪酸梭菌肠球菌三联活菌片与胶体酒石酸铋胶囊分别联合三联疗法对治疗幽门螺杆菌感染所致消化性溃疡临床效果. 方法:将150例幽门螺杆菌感检测阳性的老年消化性溃疡患者随机分为酪酸梭菌肠球菌三联活菌片组(简称活菌组)、胶体酒石酸铋胶囊组(简称胶囊组)和单纯三联组,每组50例,活菌组给予酪酸梭菌肠球菌三联活菌片联合三联疗法治疗,胶囊组给予胶体酒石酸铋胶囊联合三联疗法治疗,单纯三联组只给予标准三联治疗. 治疗5周后比较三组临床疗效、幽门螺杆菌清除率及不良反应. 结果:治疗后,活菌组总有效率为94.00%,幽门螺杆菌清除率为90.00%,均显著高于胶囊组(P<0.05);单纯三联组疗效最差(P<0.05);胶囊组存在一定的肾脏毒性. 结论:酪酸梭菌肠球菌三联活菌片联合三联疗法要优于胶体酒石酸铋胶囊联合三联疗法和单纯三联疗法,胶体酒石酸铋胶囊联合三联疗法存在一定肾毒性,对老年患者不适用,需要结合患者情况并采取询证医学辨证后选择治疗方式.
목적:비교분석락산사균장구균삼련활균편여효체주석산필효낭분별연합삼련요법대치료유문라간균감염소치소화성궤양림상효과. 방법:장150례유문라간균감검측양성적노년소화성궤양환자수궤분위락산사균장구균삼련활균편조(간칭활균조)、효체주석산필효낭조(간칭효낭조)화단순삼련조,매조50례,활균조급여락산사균장구균삼련활균편연합삼련요법치료,효낭조급여효체주석산필효낭연합삼련요법치료,단순삼련조지급여표준삼련치료. 치료5주후비교삼조림상료효、유문라간균청제솔급불량반응. 결과:치료후,활균조총유효솔위94.00%,유문라간균청제솔위90.00%,균현저고우효낭조(P<0.05);단순삼련조료효최차(P<0.05);효낭조존재일정적신장독성. 결론:락산사균장구균삼련활균편연합삼련요법요우우효체주석산필효낭연합삼련요법화단순삼련요법,효체주석산필효낭연합삼련요법존재일정신독성,대노년환자불괄용,수요결합환자정황병채취순증의학변증후선택치료방식.
Objective:Comparative analysis of GABA Fusobacterium triple viable colloidal bismuth tartrate tablets were joint capsule triple therapy for the treatment of Helicobacter pylori infection in elderly peptic ulcer clinical results. Method:The 150 cases of infection caused by Helicobacter pylori peptic ulcer in elderly patients were randomly divided into GABA Fusobacterium triple viable tablet group (referred to as the viable group), colloidal bismuth tartrate capsules group (capsule group) and pure triple groups all 50 cases, viable cells were given GABA Fusobacterium triple viable tablet combined triple therapy treatment group were given capsules colloidal bismuth tartrate capsules combined with triple therapy, a simple triple group received standard triple therapy. 4 weeks after treatment clinical efficacy of three groups of patients, H. pylori clearance and adverse reactions. Results:After treatment, the viable group, the total effective rate 94.00%, 90.00% Helicobacter pylori eradication rate were significantly higher than capsules group (P<0.05); the worst effect of pure triple group (P<0.05);there are some capsule group nephrotoxicity. Conclusion:GABA Fusobacterium triple viable tablet combined with triple therapy is superior to bismuth tartrate capsules combined with triple therapy and simple triple therapy, and colloidal bismuth tartrate capsules combined with triple therapy has some kidney toxicity, does not apply to elderly patients, requires a combination of the patient''s condition and take exercise Select the certificate of medical treatment after differentiation.