饮食保健
飲食保健
음식보건
Diet Health
2015年
8期
9-11
,共3页
氨基末端脑钠肽前体%心力衰竭
氨基末耑腦鈉肽前體%心力衰竭
안기말단뇌납태전체%심력쇠갈
Amino terminal brain natriuretic peptide precursor%heart failure
目的：探讨氨基末端脑钠肽前体（N terminal probrain natriuretic peptide，NT-proBNP）检测在75岁以上心力衰竭患者（Heart Failur，HF）的临床意义，并分析其截止点的选择。方法：选择75岁以上的HF患者136例，年龄大于75岁的健康老年人136例为对照组，对照组和HF组（治疗前）均接受心脏彩超和NT-proBNP的检测，对比两组指标差异；分别计算采用NT-proBNP （2000pg/ml）、LVEF（45%）和Fs（21%）作为截止点的敏感度、特异度和诊断符合率，并进行对比分析。结果：HF组左心室射血分数（LVEF）平均值较对照组高（P＜0.001），左室内径缩短率（Fs）较对照组低（P＜0.001），NT-proBNP较对照组明显增高（P＜0.001），且NT-proBNP随着心功能的逐渐加重而逐渐升高，两者呈正相关；使用NT-proBNP＞2000pg/ml作为诊断75岁以上AHF的指标敏感性特异度和诊断符合率较以LVEF≥45%或Fs＜21%为诊断指标较高。结论：NT-proBNP诊断HF患者具有较高的便捷性和优越性，对于75岁以上的老年人，可选择2000pg/ml作为HF的截止点。
目的：探討氨基末耑腦鈉肽前體（N terminal probrain natriuretic peptide，NT-proBNP）檢測在75歲以上心力衰竭患者（Heart Failur，HF）的臨床意義，併分析其截止點的選擇。方法：選擇75歲以上的HF患者136例，年齡大于75歲的健康老年人136例為對照組，對照組和HF組（治療前）均接受心髒綵超和NT-proBNP的檢測，對比兩組指標差異；分彆計算採用NT-proBNP （2000pg/ml）、LVEF（45%）和Fs（21%）作為截止點的敏感度、特異度和診斷符閤率，併進行對比分析。結果：HF組左心室射血分數（LVEF）平均值較對照組高（P＜0.001），左室內徑縮短率（Fs）較對照組低（P＜0.001），NT-proBNP較對照組明顯增高（P＜0.001），且NT-proBNP隨著心功能的逐漸加重而逐漸升高，兩者呈正相關；使用NT-proBNP＞2000pg/ml作為診斷75歲以上AHF的指標敏感性特異度和診斷符閤率較以LVEF≥45%或Fs＜21%為診斷指標較高。結論：NT-proBNP診斷HF患者具有較高的便捷性和優越性，對于75歲以上的老年人，可選擇2000pg/ml作為HF的截止點。
목적：탐토안기말단뇌납태전체（N terminal probrain natriuretic peptide，NT-proBNP）검측재75세이상심력쇠갈환자（Heart Failur，HF）적림상의의，병분석기절지점적선택。방법：선택75세이상적HF환자136례，년령대우75세적건강노년인136례위대조조，대조조화HF조（치료전）균접수심장채초화NT-proBNP적검측，대비량조지표차이；분별계산채용NT-proBNP （2000pg/ml）、LVEF（45%）화Fs（21%）작위절지점적민감도、특이도화진단부합솔，병진행대비분석。결과：HF조좌심실사혈분수（LVEF）평균치교대조조고（P＜0.001），좌실내경축단솔（Fs）교대조조저（P＜0.001），NT-proBNP교대조조명현증고（P＜0.001），차NT-proBNP수착심공능적축점가중이축점승고，량자정정상관；사용NT-proBNP＞2000pg/ml작위진단75세이상AHF적지표민감성특이도화진단부합솔교이LVEF≥45%혹Fs＜21%위진단지표교고。결론：NT-proBNP진단HF환자구유교고적편첩성화우월성，대우75세이상적노년인，가선택2000pg/ml작위HF적절지점。
Objective to investigate the amino terminal pro brain natriuretic peptide precursor (N terminal probrain natriuretic peptide, NT proBNP) detection in over 75 years of age or older HF) in patients with congestive heart failure (heart Failur clinical significance, and analysis the cut-off point for the choice. Methods 136 patients 75 years of age or older HF patients older than 75 years of healthy elderly people 136 cases as control group, control group and HF group (before treatment) underwent echocardiography and NT proBNP detection, differences between two groups of indices, were calculated using left ventricular ejection fraction (LVEF) and NT proBNP (2000pg/ml) (45%) and FS (21%) as a cutoff point of sensitivity, specificity, and diagnostic coincidence rate, and carries on the contrast analysis. Results HF group, the left ventricular ejection fraction (LVEF) mean value is higher than the control group (P<0.001) , left ventricular internal diameter shortening (FS) compared with the control group (P<0.001) , NT proBNP than the control group increased significantly (P<0.001) and NT proBNP with cardiac function of gradually increasing, there was a positive correlation between;use NT proBNP>2000pg/ml as diagnosis over the age of 75 AHF index sensitivity specificity and diagnostic coincidence rate compared with left ventricular ejection fraction (LVEF) is more than or equal to 45%or FS<21%higher diagnostic index. Conclusion NT-proBNP has a high convenience and superiority in the diagnosis of HF, and can choose 2000pg/ml as the cutoff point of HF for the elderly over 75 years old.
