CAJ | 학술논문

目的探讨盐酸曲美他嗪对合并糖尿病患者急诊PCI术后的疗效及安全性. 方法将150例合并糖尿病的急性心肌梗死( AMI)患者行急诊PCI后随机分为实验组和对照组,其中实验组75例,对照组75例,对照组常规给予冠心病二级预防药物治疗,观察组在常规治疗组的基础上加用曲美他嗪治疗,两组患者均随访12个月,观察两组患者术后12个月的心血管事件发生率、心肌功能情况、糖化血红蛋白水平及血清肌酐清除率的变化情况. 结果观察组术后12 个月LVEDD小于对照组、LVEF大于对照组,组间比较差异有显著性(P<0.05). 随访心血管事件总发生率、胸痛及心衰入院发生率明显低于对照组,两组比较差异有显著性(P<0.05),而术后12个月复查血清肌酐清除率和糖化血红蛋白无差别. 结论盐酸曲美他嗪应用于合并糖尿病患者急诊PCI术后是安全有效的.
목적 탐토염산곡미타진대합병당뇨병환자급진PCI술후적료효급안전성. 방법 장150례합병당뇨병적급성심기경사( AMI)환자행급진PCI후수궤분위실험조화대조조,기중실험조75례,대조조75례,대조조상규급여관심병이급예방약물치료,관찰조재상규치료조적기출상가용곡미타진치료,량조환자균수방12개월,관찰량조환자술후12개월적심혈관사건발생솔、심기공능정황、당화혈홍단백수평급혈청기항청제솔적변화정황. 결과 관찰조술후12 개월LVEDD소우대조조、LVEF대우대조조,조간비교차이유현저성(P<0.05). 수방심혈관사건총발생솔、흉통급심쇠입원발생솔명현저우대조조,량조비교차이유현저성(P<0.05),이술후12개월복사혈청기항청제솔화당화혈홍단백무차별. 결론염산곡미타진응용우합병당뇨병환자급진PCI술후시안전유효적.
Objective To discuss the efficacy and safety of Trimetazidine hydrochloride in the treatment of AMI patients who suffered emergency PCI operation and complicated with diabetes .Methods 150 cases of patients with acute myocardial infarction ( AMI) patients underwent emergency PCI and complicated with diabetes were randomly divided into experimental group and control group , 75 cases in experiment group and 75 cases in the control group .Patients in the control group were given conventional drug treatment for secondary prevention of coronary heart disease , however , the patients in observation group were given Trimetazidine on the basis of conventional treatment , patients of both groups were followed up for 12 months.Occurrence rate of cardiovascular event , changes of myocardial function , the level of glycosylated hemoglobin and serum creatinine clearance rate of the two groups were observed .Results In the observation group , after 12 months, LVEDD was less than that of the control group , on the contrast the LVEF was greater than the control group , and there was significant difference between the two groups (P<0.05).The total incidence of cardiovascular events , chest pain and heart failure caused hospitalization in experimental group was significantly lower than the control group , there were significant difference between the two groups (P<0.05).And the differences of serum creatinine clearance rate and glycosylated hemoglobin between the two groups were not statistically significant on 12 months after operation . Conclusions The application of Trimetazidine hydrochloride in AMI patients received PCI surgery and complicated with diabetes is safe and effective .