CAJ | 학술논문

采用“药物修饰-共组装”法制备了(羟基喜树碱@胆酸钠)-层状双金属氢氧化物纳米杂化物.先用胆酸钠(SCL)包裹羟基喜树碱(HCPT)形成胶束,再与微反应器制备的层状双氢氧化物(LDH)纳米片共组装形成纳米杂化物,其载药量可达12.9%,杂化物中 HCPT 以高生物活性的内酯形式存在.采用聚乙二醇(PEG)和羧甲基纤维素(CMC)分别对所制备的(HCPT@ SCL)-LDH 纳米杂化物进行了表面修饰,结果表明,纳米杂化物的分散性得到明显改善； PEG 的修饰效果优于 CMC,所获得的 PEG-(HCPT@ SCL)-LDH 杂化物的平均粒径可小至约70 nm,具有良好的分散性和药物缓释效果.其药物释放过程可用准二级动力学方程描述,颗粒内部扩散是药物释放过程的控制步骤.
채용“약물수식-공조장”법제비료(간기희수감@담산납)-층상쌍금속경양화물납미잡화물.선용담산납(SCL)포과간기희수감(HCPT)형성효속,재여미반응기제비적층상쌍경양화물(LDH)납미편공조장형성납미잡화물,기재약량가체12.9%,잡화물중 HCPT 이고생물활성적내지형식존재.채용취을이순(PEG)화최갑기섬유소(CMC)분별대소제비적(HCPT@ SCL)-LDH 납미잡화물진행료표면수식,결과표명,납미잡화물적분산성득도명현개선； PEG 적수식효과우우 CMC,소획득적 PEG-(HCPT@ SCL)-LDH 잡화물적평균립경가소지약70 nm,구유량호적분산성화약물완석효과.기약물석방과정가용준이급동역학방정묘술,과립내부확산시약물석방과정적공제보취.
( Hydroxyl camptothecin @ sodium cholate)-layered double hydroxide ( LDH) nanohybrids were prepared by a modified drug-coassembly method. Firstly, Hydroxyl camptothecin(HCPT) was incorporated in-to micelles derived from sodium cholate(SCL) which negatively charged. The negatively charged micelles in-tercalated HCPT@ SCL-LDH nanohybrids were prepared by a co-assembly between LDH nanosheets and sodi-um cholate micelles with the encapsulated HCPT could keep the biological active lactone form, and the drug loading of so-obtained nanohybrid was 12. 9% . (HCPT@ SCL)-LDH was modified using polyethylene glycol (PEG) and carboxymethylcellulose(CMC), respectively. The results showed that the dispersity of nanohy-brids was obviously improved, and PEG worked better than CMC. The PEG-(HCPT@ SCL)-LDH had favora-ble dispersity with average size of ca. 70 nm. PEG-(HCPT@ SCL)-LDH showed well controlled release prop-erty and in vitro drug release kine-tics from the nanohybrids could be fitted with the pseudo-second-order kinet-ic model. The diffusion of HCPT through the LDH particles played an important role in controlling the drug re-lease.