CAJ | 학술논문

目的：探讨125 I粒子植入术治疗脑胶质瘤的近期疗效与安全性。方法回顾性分析青岛大学附属医院2013年6月～2014年6月收治的32例脑胶质瘤患者，其中术后复发患者13例，已行外放疗后复发7例，初始治疗12例。采用C T引导下125 I放射性粒子植入术治疗，术后随访6月（3个半衰期），观察分析术后并发症和疗效。结果32例患者治疗后复查均无颅内出血病例。6例（18．8％）术后出现恶心、呕吐，给予止吐、降低颅内压处理后缓解。4例（12．5％）患者出现外周血白细胞轻度下降（不低于3×109／L ），给予升白药物治疗后恢复正常。监测肝肾功能治疗前后无明显变化。125 I粒子植入术后2个月、6个月（3个半衰期）随访，术后2月32例患者中CR25．0％（8／32）、PR34．4％（11／32）、NC28．1％（9／32）、PD12．5％（4／32），有效率（CR＋ PR）59．4％。术后6月C R 34．4％（11／32）、PR37．5％（12／32）、NC21．9％（7／32），PD6．3％（2／32），有效率（CR ＋PR）71．9％。32例中无死亡及病变进展病例。结论125 I放射性粒子植入治疗脑胶质瘤是微创的、安全的，具有显著的近期疗效。
목적：탐토125 I입자식입술치료뇌효질류적근기료효여안전성。방법회고성분석청도대학부속의원2013년6월～2014년6월수치적32례뇌효질류환자，기중술후복발환자13례，이행외방료후복발7례，초시치료12례。채용C T인도하125 I방사성입자식입술치료，술후수방6월（3개반쇠기），관찰분석술후병발증화료효。결과32례환자치료후복사균무로내출혈병례。6례（18．8％）술후출현악심、구토，급여지토、강저로내압처리후완해。4례（12．5％）환자출현외주혈백세포경도하강（불저우3×109／L ），급여승백약물치료후회복정상。감측간신공능치료전후무명현변화。125 I입자식입술후2개월、6개월（3개반쇠기）수방，술후2월32례환자중CR25．0％（8／32）、PR34．4％（11／32）、NC28．1％（9／32）、PD12．5％（4／32），유효솔（CR＋ PR）59．4％。술후6월C R 34．4％（11／32）、PR37．5％（12／32）、NC21．9％（7／32），PD6．3％（2／32），유효솔（CR ＋PR）71．9％。32례중무사망급병변진전병례。결론125 I방사성입자식입치료뇌효질류시미창적、안전적，구유현저적근기료효。
Objective To investigate the short‐term efficacy and safety of to investigate the 125 I seed implantation treat‐ment of glioma .Methods A retrospective analysis was perfomed in 32 patients with glioma ,who received CT‐guided 125 I radioactive seeds implantation therapy in the Affiliated Hospital of Qingdao University from Apr .2013 to Jun .2014 .The postoperative follow‐up was six months and the postoperative complications and efficacy were analyzed .Results None of 32 patients had no intracranial hemorrhage post -treatment .6 cases (18 .8% ) appeared postoperative nausea and vomi‐ting ,which were relieved after treatment with antiemetic and reducing the intracranial pressure .4 cases (12 .5% ) had slightly decreased peripheral blood leukocytes (not less than 3 × 109/L) ,which returned to normal after drug treatment . No significant changes in liver and kidney function were monitored before and after treatment .Follow -up of 125 I implanta‐tion was conducted for 2 months and 6 months (three half‐life) .The results among 32 patients after two -month were as follows :CR25 .0% (8/32) ,PR34 .4% (11/32) ,NC28 .1% (9/32) ,PD12 .5% (4/32) ,and efficiency (CR + PR) 59.4% .Those at 6 months were CR 34 .4% (11/32) ,PR37 .5% (12/32) ,NC21 .9% (7/32) ,PD6 .3% (2/32) ,and ef‐ficiency (CR + PR) up to 71 .9% .There were no deaths and cases of disease progression in 32 cases .Conclusion 125 I seeds implantation is a minimally invasive treatment for glioma ,which has a significant short‐term effect .