亚太热带生物医学杂志（英文版）
亞太熱帶生物醫學雜誌（英文版）
아태열대생물의학잡지（영문판）
Asian pacific Journal of Tropical Biomedicine
2011年
2期
142-146
,共5页
Hepax%Paracetamol%CCl4%Thiocetamide%Hepatotoxicity
Objective:To evaluate the hepatoprotective potential of Hepax, a polyherbal formulation, against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models, namely, carbon tetrachloride (CCl4), paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins (CCl4, paracetamol and thiocetamide) showed significant morphological, biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters (liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters (SGPT, SGOT, ALP and total bilirubin), which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at100 and200 mg/kg,p.o. on the liver of all the three experimental animal models.
