中外医学研究
中外醫學研究
중외의학연구
Chinese and Foreign Medical Research
2015年
28期
21-23
,共3页
林道建%王华芳%麦卫华%赵飞
林道建%王華芳%麥衛華%趙飛
림도건%왕화방%맥위화%조비
流感病毒裂解疫苗%不良反应%进口%国产
流感病毒裂解疫苗%不良反應%進口%國產
류감병독렬해역묘%불량반응%진구%국산
Influenza Split Vaccine%Adverse reaction%Imported%Domestic
目的：探讨国产和进口两个不同厂家流感病毒裂解疫苗的安全性。方法：通过电话随访和开放式问卷统计2013年9月-2014年1月在中山大学附属第五医院计免门诊接种流感疫苗的568例对象，除去不接受随访的对象，选出391例作为调查对象，追踪观察接种流感疫苗后一周内出现不良反应的症状与体征。将391例研究对象分为6~35个月组和≥3岁组，通过SPSS 19.0软件进行统计学分析，讨论两种疫苗不良反应的差异。结果：葛兰素与华兰生物的流感疫苗总体不良反应发生率分别为4.2%和9.9%，差异有统计学意义(字2=5.016，P<0.05)。6~35个月进口与国产不良反应发生率分别为3.9%和11.8%，差异有统计学意义(字2=6.029，P<0.05)，其中局部反应的发生率为0.6%和4.6%，差异有统计学意义(字2=4.439，P<0.05)。然而≥3岁组进口与国产不良反应发生率分别为4.7%和4.8%，差异无统计学意义(字2<0.001，P>0.05)。结论：6~35个月儿童葛兰素史克的流感疫苗较华兰生物的安全性高。
目的：探討國產和進口兩箇不同廠傢流感病毒裂解疫苗的安全性。方法：通過電話隨訪和開放式問捲統計2013年9月-2014年1月在中山大學附屬第五醫院計免門診接種流感疫苗的568例對象，除去不接受隨訪的對象，選齣391例作為調查對象，追蹤觀察接種流感疫苗後一週內齣現不良反應的癥狀與體徵。將391例研究對象分為6~35箇月組和≥3歲組，通過SPSS 19.0軟件進行統計學分析，討論兩種疫苗不良反應的差異。結果：葛蘭素與華蘭生物的流感疫苗總體不良反應髮生率分彆為4.2%和9.9%，差異有統計學意義(字2=5.016，P<0.05)。6~35箇月進口與國產不良反應髮生率分彆為3.9%和11.8%，差異有統計學意義(字2=6.029，P<0.05)，其中跼部反應的髮生率為0.6%和4.6%，差異有統計學意義(字2=4.439，P<0.05)。然而≥3歲組進口與國產不良反應髮生率分彆為4.7%和4.8%，差異無統計學意義(字2<0.001，P>0.05)。結論：6~35箇月兒童葛蘭素史剋的流感疫苗較華蘭生物的安全性高。
목적：탐토국산화진구량개불동엄가류감병독렬해역묘적안전성。방법：통과전화수방화개방식문권통계2013년9월-2014년1월재중산대학부속제오의원계면문진접충류감역묘적568례대상，제거불접수수방적대상，선출391례작위조사대상，추종관찰접충류감역묘후일주내출현불량반응적증상여체정。장391례연구대상분위6~35개월조화≥3세조，통과SPSS 19.0연건진행통계학분석，토론량충역묘불량반응적차이。결과：갈란소여화란생물적류감역묘총체불량반응발생솔분별위4.2%화9.9%，차이유통계학의의(자2=5.016，P<0.05)。6~35개월진구여국산불량반응발생솔분별위3.9%화11.8%，차이유통계학의의(자2=6.029，P<0.05)，기중국부반응적발생솔위0.6%화4.6%，차이유통계학의의(자2=4.439，P<0.05)。연이≥3세조진구여국산불량반응발생솔분별위4.7%화4.8%，차이무통계학의의(자2<0.001，P>0.05)。결론：6~35개월인동갈란소사극적류감역묘교화란생물적안전성고。
Objective:To explore the safety about domestic and imported Influenza Split Vaccine from two different manufacturers. Method:Statistics via telephone and open questionnaire showed that there had been 568 cases taking Influenza Vaccine in The Fifth Affiliated Hospital, Sun Yat-sen University from Sep 2013 to Jan 2014.Excluding those people who were not willing to accept the follow-up survey,391 cases were observed on symptoms and signs of adverse reactions within one week after taking influenza vaccine.They were divided into two groups.One was 6-35 months-old group,the other was≥3 years-old group.Then we did statistical analysis with SPSS 19.0 software,and discussed the significance of differences between the adverse reactions caused by these two kinds of vaccine.Result:The Influenza Vaccine adverse reaction rates of Glaxo and Hualan Biological were 4.2%and 9.9%,there were statistically significant(χ2=5.016,P<0.05).The adverse reaction rates of imported and domestic Influenza Vaccine among the 6-35 months-old group were 3.9%and 11.8%,there were statistically significant(χ2=6.029,P<0.05),the local adverse reaction rate were 0.6%and 4.6%, there were statistically significant(χ2=4.439,P<0.05).However,≥3 years-old group,the adverse reaction rates of imported and domestic Influenza Vaccine were 4.7%and 4.8%,there were no statistically significant(χ2<0.001,P>0.05).Conclusion:The Influenza Vaccine from Glaxo Smith Kline is safer than the one from Hualan Biological for 6-35 months-old people.
