CAJ | 학술논문

目的：通过观察针刺对肝郁化火型失眠患者的5-HT含量以及治疗效果的影响,探讨针刺法治疗肝郁化火型失眠的应用价值以及理论基础。方法选取肝郁化火型失眠患者共187例为研究对象,随机分为两组,对照组93例给予曲唑酮口服,每次100 mg,每日2次,10 d为1个疗程,共治疗2个疗程；观察组94例针刺神门、百会、印堂、合谷、太冲,每日1次,治疗10 d为1个疗程,共治疗2个疗程。两组患者治疗前后均抽取外周血液,检测5-HT含量变化,同时进行匹兹堡睡眠质量指数评定量表(PSQI)、汉密尔顿抑郁量表24项版(HAMD)、Asberg副作用量表(SERS)以及临床疗效评价。结果两组患者治疗前5-HT含量无显著性差异(P＞0.05)；两组治疗后5-HT含量虽然均见显著升高(P＜0.05),观察组患者5-HT含量显著高于对照组(P＜0.05)；两组患者治疗后PSQI以及HAMD评分均见降低(P＜0.05),观察组患者PSQI、HAMD以及SERS评分显著低于对照组(P＜0.05)；观察组总有效率(92.6%)显著高于对照组(81.7%)(P＜0.05)。结论针刺能够显著降低失眠患者5-HT含量,总有效率优于药物治疗。
목적：통과관찰침자대간욱화화형실면환자적5-HT함량이급치료효과적영향,탐토침자법치료간욱화화형실면적응용개치이급이론기출。방법선취간욱화화형실면환자공187례위연구대상,수궤분위량조,대조조93례급여곡서동구복,매차100 mg,매일2차,10 d위1개료정,공치료2개료정；관찰조94례침자신문、백회、인당、합곡、태충,매일1차,치료10 d위1개료정,공치료2개료정。량조환자치료전후균추취외주혈액,검측5-HT함량변화,동시진행필자보수면질량지수평정량표(PSQI)、한밀이돈억욱량표24항판(HAMD)、Asberg부작용량표(SERS)이급림상료효평개。결과량조환자치료전5-HT함량무현저성차이(P＞0.05)；량조치료후5-HT함량수연균견현저승고(P＜0.05),관찰조환자5-HT함량현저고우대조조(P＜0.05)；량조환자치료후PSQI이급HAMD평분균견강저(P＜0.05),관찰조환자PSQI、HAMD이급SERS평분현저저우대조조(P＜0.05)；관찰조총유효솔(92.6%)현저고우대조조(81.7%)(P＜0.05)。결론침자능구현저강저실면환자5-HT함량,총유효솔우우약물치료。
ObjectiveTo explore the value of acupuncture in treating insomnia due to stagnated liverqi transforming into fire and its theoretical foundation, by observing the treatment effect of acupuncture in treating insomnia due to stagnated liverqi transforming into fire and its influence on 5-hydroxy tryptamine (5-HT) content.MethodTotally 187patients with insomnia due to stagnated liver qi transforming into fire were selected and randomized into two groups. The 93 cases in the control group were intervened by orally taking Trazodone, 100 mg for each dose, twice a day, 10 d as a course, totallyfor 2 courses; the 94 cases in the observation group were intervened by acupuncture at Shenmen (HT7), Baihui (GV20), Yintang (GV29), Hegu (LI 4), and Taichong (LR 3), once a day, 10 d as a treatment course, totally for 2 courses. Peripheral blood was collected from the two groups before and after intervention to detect the change of 5-HT content. Meanwhile, the Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale (HAMD, 24-item version), Asberg Rating Scale for Side Effects (SERS), and clinicalefficacies were assessed.ResultThe difference in 5-HT content between the two groups was statistically insignificant before intervention (P>0.05); 5-HT contents were significantly increased in both groups after intervention (P<0.05), while the content in the observation group was markedly higher than that in the control group (P<0.05); after treatment, the PSQI and HAMD scores were decreasedin both groups (P<0.05), while the PSQI, HAMD, and SERS scores in the observation group were markedly lower than those in the control group (P<0.05);the total effective rate was 92.6% in the observation group, significantly higher than 81,7% in the control group (P<0.05). ConclusionAcupuncture can significantly down-regulate 5-HT content in insomnia patients, and its total effective rate is higher than that of medication.