CAJ | 학술논문

目的：观察针刺配合心理干预对产后抑郁患者的临床疗效及5-HT、OFQ 和 E2水平的影响。方法采用随机分组的方法,将158例产后抑郁症患者分为针刺组、心理干预组和治疗组,针刺组52例,心理干预组和治疗组各53例。针刺组给予针刺治疗,心理干预组给予心理干预治疗,治疗组给予针刺配合心理干预治疗。治疗6星期后,观察患者的临床疗效、HAMD分值、SDS、SAS、5-HT、OFQ和E2。结果治疗组总有效率为92.5%,心理干预组为79.2%,针刺组为76.9%。Ridit分析显示治疗组疗效明显优于心理干预组和针刺组(P＜0.05),针刺组与心理干预组比较差异无统计学意义(P＞0.05)。治疗组治疗后HAMD分值、SAS、SDS、5-HT、OFQ和E2与针刺组比较差异均有统计学意义(P＜0.01)；治疗组治疗后HAMD分值、SAS、SDS、5-HT、OFQ和E2与心理干预组比较差异有统计学意义(P＜0.01)；心理干预组治疗后HAMD分值、5-HT、OFQ和E2与针刺组比较差异无统计学意义(P＞0.05),但心理干预组治疗后SAS和SDS与针刺组比较差异有统计学意义(P＜0.01)。结论针刺配合心理干预治疗能明显提高产后抑郁患者的临床疗效,改善HAMD分值,并能明显降低患者的SAS和SDS,调节5-HT、OFQ和E2含量水平。
목적：관찰침자배합심리간예대산후억욱환자적림상료효급5-HT、OFQ 화 E2수평적영향。방법채용수궤분조적방법,장158례산후억욱증환자분위침자조、심리간예조화치료조,침자조52례,심리간예조화치료조각53례。침자조급여침자치료,심리간예조급여심리간예치료,치료조급여침자배합심리간예치료。치료6성기후,관찰환자적림상료효、HAMD분치、SDS、SAS、5-HT、OFQ화E2。결과치료조총유효솔위92.5%,심리간예조위79.2%,침자조위76.9%。Ridit분석현시치료조료효명현우우심리간예조화침자조(P＜0.05),침자조여심리간예조비교차이무통계학의의(P＞0.05)。치료조치료후HAMD분치、SAS、SDS、5-HT、OFQ화E2여침자조비교차이균유통계학의의(P＜0.01)；치료조치료후HAMD분치、SAS、SDS、5-HT、OFQ화E2여심리간예조비교차이유통계학의의(P＜0.01)；심리간예조치료후HAMD분치、5-HT、OFQ화E2여침자조비교차이무통계학의의(P＞0.05),단심리간예조치료후SAS화SDS여침자조비교차이유통계학의의(P＜0.01)。결론침자배합심리간예치료능명현제고산후억욱환자적림상료효,개선HAMD분치,병능명현강저환자적SAS화SDS,조절5-HT、OFQ화E2함량수평。
ObjectiveTo observe the clinical efficacy of acupuncture plus psychological intervention in treating postpartum depression and its effect on 5-hydroxy tryptamine (5-HT), orphanin FQ (OFQ) and estrodiol (E2).MethodTotally 158patients with postpartum depression were randomized into an acupuncture group, a psychological intervention group, and a treatment group, 52 cases in the acupuncture group, and 53 cases respectively in the psychological intervention group and treatment group. The acupuncture group was given acupuncture, the psychological intervention group was given psychological intervention, while the treatment group was given acupuncture plus psychological intervention. After 6-week treatment, the clinical efficacies, the Hamilton Depression Scale (HAMD) score, Self-rating Depression Scale (SDS) score, Self-rating Anxiety Scale (SAS) score, 5-HT, OFQ, and E2were observed.ResultThe total effective rate was 92.5% in the treatment group, versus 79.2% in the psychological intervention group and 76.9% in the acupuncture group. TheRiditanalysis showed that the therapeutic efficacy of the treatment group was significantly superior to that of the psychological intervention group and acupuncture group (P<0.05), while there was no significant difference between the acupuncture group and psychological intervention group (P>0.05). After treatment, the HAMD score, SAS score, SDS score, 5-HT, OFQ, and E2levels were significantly different from those in the acupuncture group (P<0.01); after treatment, the HAMD score, SAS score, SDS score, 5-HT, OFQ, and E2levels of the treatment group were significantly different from those in the psychological intervention group (P<0.01); after treatment, the HAMD score, 5-HT, OFQ, and E2levelsof the psychological intervention group were insignificantly different from those of the acupuncture group (P>0.05), while there were significant differences in comparing the SAS and SDS scores between the two groups (P<0.01).ConclusionAcupuncture plus psychological intervention can markedly enhance the clinical efficacy in treating postpartum depression, improving HAMD score, decreasing SAS and SDS scores, and regulating the 5-HT, OFQ, and E2levels.