CAJ | 학술논문

目的探讨广西壮族人群中ABO血型与冠心病的相关性.方法回顾性纳入2010年8月至2013年4月在广西壮族自治区人民医院心内科住院的广西壮族冠心病患者1 024例,并选取广西壮族自治区人民医院体检中心1 024例广西壮族对照进行分析.所有研究对象按标准流程检测ABO血型、血脂、空腹血糖(FBG)、C反应蛋白(CRP)等各项生化指标.对入选患者中的976例(95.3％)行冠状动脉造影的广西壮族冠心病患者进行Gensini评分以评估冠状动脉病变严重程度,记录随访1年的主要不良心血管事件(MACE)发生情况.结果与对照组(1 024例)比较,冠心病组(1 024例)的FBG[(6.71 ±6.72) mmol/L比(4.98 ±1.55) mmol/L,P＜0.001]、低密度脂蛋白胆固醇[(2.89±1.18) mmol/L比(2.60±1.05) mmol/L,P=0.002]及CRP水平[(7.74±7.32) mg/L比(2.93 ±2.19) mg/L,P＜0.001]较高,且高血压(57.0％比27.5％,P＜0.001)、2型糖尿病(29.6％比9.6％,P ＜0.001)及冠心病家族史(35.3％比10.6％,P＜0.001)、吸烟史(51.0％比38.2％,P＜0.001)的比例较高.logistic回归分析显示ABO血型与广西壮族人群冠心病相关,B血型患冠心病的风险明显高于O血型(OR =2.33,95％ CI 1.88 ～2.90,P＜0.001);对冠心病传统危险因素进行校正后,该风险仍然存在(OR=1.55,95％CI1.05 ～2.52,P=0.047).多因素协方差分析结果提示在广西壮族冠心病患者中非O血型患者Gensini评分高于O血型患者(41.2 ±26.8比36.7 ±31.3,P=0.038).但随访1年的MACE累计风险概率在不同血型的冠心病患者中差异无统计学意义(P＞0.05).结论 ABO血型与广西壮族人群冠心病发病风险相关,B血型较O血型更易患冠心病.
목적 탐토엄서장족인군중ABO혈형여관심병적상관성.방법 회고성납입2010년8월지2013년4월재엄서장족자치구인민의원심내과주원적엄서장족관심병환자1 024례,병선취엄서장족자치구인민의원체검중심1 024례엄서장족대조진행분석.소유연구대상안표준류정검측ABO혈형、혈지、공복혈당(FBG)、C반응단백(CRP)등각항생화지표.대입선환자중적976례(95.3％)행관상동맥조영적엄서장족관심병환자진행Gensini평분이평고관상동맥병변엄중정도,기록수방1년적주요불양심혈관사건(MACE)발생정황.결과 여대조조(1 024례)비교,관심병조(1 024례)적FBG[(6.71 ±6.72) mmol/L비(4.98 ±1.55) mmol/L,P＜0.001]、저밀도지단백담고순[(2.89±1.18) mmol/L비(2.60±1.05) mmol/L,P=0.002]급CRP수평[(7.74±7.32) mg/L비(2.93 ±2.19) mg/L,P＜0.001]교고,차고혈압(57.0％비27.5％,P＜0.001)、2형당뇨병(29.6％비9.6％,P ＜0.001)급관심병가족사(35.3％비10.6％,P＜0.001)、흡연사(51.0％비38.2％,P＜0.001)적비례교고.logistic회귀분석현시ABO혈형여엄서장족인군관심병상관,B혈형환관심병적풍험명현고우O혈형(OR =2.33,95％ CI 1.88 ～2.90,P＜0.001);대관심병전통위험인소진행교정후,해풍험잉연존재(OR=1.55,95％CI1.05 ～2.52,P=0.047).다인소협방차분석결과제시재엄서장족관심병환자중비O혈형환자Gensini평분고우O혈형환자(41.2 ±26.8비36.7 ±31.3,P=0.038).단수방1년적MACE루계풍험개솔재불동혈형적관심병환자중차이무통계학의의(P＞0.05).결론 ABO혈형여엄서장족인군관심병발병풍험상관,B혈형교O혈형경역환관심병.
Objective To investigate this association between ABO blood groups and coronary heart disease (CHD) in the Chinese Guangxi Zhuang population.Methods From August 2010 to April 2013,we performed a case-control study in a Chinese Zhuang population,which included 1 024 CHD cases and 1 024 age and gender-matched non-CHD controls.The ABO blood groups and biological variables were measured by standard laboratory procedures.The Gensini score was used to evaluate the severity of coronary artery stenosis.Results Compared to non-CHD control group,CHD group had higher levels of fasting blood glucose((6.71 ±6.72) mmol/L vs.(4.98 ± 1.55) mmol/L,P ＜0.001),LDL-C ((2.89 ± 1.18) mmol/L vs.(2.60±1.05) mmol/L,P=0.002) and CRP ((7.74 ± 7.32) mg/L vs.(2.93 ± 2.19) mg/L,P＜ 0.001) as well as higher proportion of history of hypertension(57.0％ vs.27.5％,P ＜0.001),history of diabetes(29.6％ vs.9.6％,P ＜ 0.001),family history of CHD (35.3％ vs.10.6％,P ＜ 0.001) and smoking(51.0％ vs.38.2％,P ＜ 0.001).Logistic analysis indicated that ABO blood groups were associated with CHD risk in the Chinese Zhuang population.Compared with group O,the group B individuals had a higher risk of CHD (OR =2.33,95％ CI 1.88-2.90,P ＜ 0.001),this result remained after adjustment for the conventional CHD risk factors (OR =1.55,95％ CI 1.05-2.52,P =0.047).In addition,there were significant differences of Gensini score between non-O subjects and group O subjects in the CHD group,and MACE at 1-year follow-up was similar between ABO blood groups of CHD individuals.Conclusion ABO blood groups are associated with CHD risk in the Chinese Zhuang population.