CAJ | 학술논문

目的研究ABO血型与急性心肌梗死的相关性.方法对阜外心血管病医院2013年l至12月收治入院的1 988例急性心肌梗死(AMI)患者以及l 856例非冠心病患者的ABO血型等临床资料进行回顾性分析.采用Pearson卡方检验及logistic多元回归分析模型进行统计分析.P＜0.05为差异有统计学意义.结果 AMI组中A血型539例(27.1％),B血型684例(34.4％),AB血型215例(10.8％),O血型551例(27.7％).对照组中A血型496例(26.7％),B血型598例(32.2％),AB血型200例(10.8％),O血型564例(30.4％),AMI组与对照组的ABO血型分布差异无统计学意义.血型按O型与非O型分组,对照组中O型的比例略高于AMI组,但差异无统计学意义(P=0.06).经logistic多元回归分析,在调整年龄、性别、高血压病、糖尿病、胆固醇水平和吸烟等心肌梗死危险因素后,A血型者(OR=1.229,95％ CI:1.019～1.482,P=0.031)和B血型者(OR=1.214,95％ CI:1.017～1.449,P=0.032)罹患AMI的风险显著高于O血型者;非O血型者罹患AMI的风险显著高于O血型者(OR=1.223,95％ CI:1.048～1.426,P=0.01).结论提示非O血型与AMI存在着独立相关性,非O血型可能增加AMI的发生风险.
목적 연구ABO혈형여급성심기경사적상관성.방법 대부외심혈관병의원2013년l지12월수치입원적1 988례급성심기경사(AMI)환자이급l 856례비관심병환자적ABO혈형등림상자료진행회고성분석.채용Pearson잡방검험급logistic다원회귀분석모형진행통계분석.P＜0.05위차이유통계학의의.결과 AMI조중A혈형539례(27.1％),B혈형684례(34.4％),AB혈형215례(10.8％),O혈형551례(27.7％).대조조중A혈형496례(26.7％),B혈형598례(32.2％),AB혈형200례(10.8％),O혈형564례(30.4％),AMI조여대조조적ABO혈형분포차이무통계학의의.혈형안O형여비O형분조,대조조중O형적비례략고우AMI조,단차이무통계학의의(P=0.06).경logistic다원회귀분석,재조정년령、성별、고혈압병、당뇨병、담고순수평화흡연등심기경사위험인소후,A혈형자(OR=1.229,95％ CI:1.019～1.482,P=0.031)화B혈형자(OR=1.214,95％ CI:1.017～1.449,P=0.032)리환AMI적풍험현저고우O혈형자;비O혈형자리환AMI적풍험현저고우O혈형자(OR=1.223,95％ CI:1.048～1.426,P=0.01).결론 제시비O혈형여AMI존재착독립상관성,비O혈형가능증가AMI적발생풍험.
Objective To explore the association between the ABO blood group and the risk of myocardial infarction in Chinese people.Methods We retrospectively recruited 1 988 consecutive patients with acute myocardial infarction (AMI) and 1 856 non-coronary artery disease (non-CAD) subjects who hospitalized in our hospital between January 2013 and December 2013.The clinical features and ABO blood group were analyzed.Results Blood group distribution was A (27.1％,539/1 988),B (34.4％,684/1 988),AB(10.8％,215/1 988),O (27.7％,551/1 988) in patients with AMI and A (26.7％,496/1 856),B(32.2％,598/1 856),AB (10.8％,200/1 856),O (30.4％,564/1 856) in non-CAD group.The single factor analysis showed that blood group O tended to be more common in the non-CAD group than in AMI group (P =0.06).After adjustment for common cardiovascular risk factors such as age,gender,hypertension,diabetes,smoking and serum cholesterol level,the A,B,and AB blood groups were associated with increased risk of AMI compared with O blood group,and the difference was significant with A blood group (OR =1.229,95％ CI 1.019-1.482,P =0.031) and B blood groups (OR =1.214,95％ CI 1.017-1.449,P =0.032).In addition,non-O blood group remained significantly associated with the increased risk of AMI than O blood group after logistic regression analysis(OR =1.223,95％ CI 1.048-1.426,P =0.01).Conclusion Our results suggest that non-O blood group is associated with the increased risk of AMI.