CAJ | 학술논문

目的：利用3D 1H‐MR波谱（MRS）分析方法定量分析中央腺体区前列腺癌（cPCa）的侵袭性。方法对经直肠内B超引导下穿刺活检病理证实的20例cPCa进行M RS定量分析，将前列腺中央腺体区分为6区，根据取材位置归入相应分区，测量并计算各区的（胆碱＋肌酸）／枸橼酸盐（CC／C ）的比值，将其与相应的Gleason评分及病变危险程度进行对照分析。结果20例患者共120个分区，72个分区有癌，cPCa的CC／C比值与Gleason评分呈正相关（ r ＝0．597， P ＝0．000）。低危（Gleason评分＜7分）cPCa的CC／C比值的中值1．05（0．56～1．72），高危（Gleason评分≥7分）cPCa比值的中值2．96（0．96～12．58），两者差异有统计学意义（ Z＝‐5．675，P＝0．000）；区分两者的ROC曲线下面积0．968。结论 cPCa的CC／C与Gleason评分呈正相关，且能够较好的区分低危及高危肿瘤。
목적：이용3D 1H‐MR파보（MRS）분석방법정량분석중앙선체구전렬선암（cPCa）적침습성。방법대경직장내B초인도하천자활검병리증실적20례cPCa진행M RS정량분석，장전렬선중앙선체구분위6구，근거취재위치귀입상응분구，측량병계산각구적（담감＋기산）／구연산염（CC／C ）적비치，장기여상응적Gleason평분급병변위험정도진행대조분석。결과20례환자공120개분구，72개분구유암，cPCa적CC／C비치여Gleason평분정정상관（ r ＝0．597， P ＝0．000）。저위（Gleason평분＜7분）cPCa적CC／C비치적중치1．05（0．56～1．72），고위（Gleason평분≥7분）cPCa비치적중치2．96（0．96～12．58），량자차이유통계학의의（ Z＝‐5．675，P＝0．000）；구분량자적ROC곡선하면적0．968。결론 cPCa적CC／C여Gleason평분정정상관，차능구교호적구분저위급고위종류。
Objective To quantitatively assess the inuision of central gland prostate cancer (cPCa) .Methods Twenty cases of cPCa proved by transrectal ultrasound guided biopsy were examined by MRS using 3D 1H‐magnetic resonance spectroscopy (MRS) .The central gland was divided into 6 regions .The (Choline +Creatine)/Citrate (CC/C) value of each region was measured .The relationship between mean CC/C of each region and Gleason score was determined .Results Of 20 cases with a total of 120 regions ,72 regions were prostate cancer .CC/C ratio was positively correlated with Gleason score of cPCa ( r =0 .597 ,P =0 .000) .Low risk (Gleason score <7) cPCa CC/C 1 .05 (0 .56~1 .72) ,median risk (7 points of Gleason score ≥ 2 .96 in median) cPCa (0 .96~12 .58) ,the difference was statistically significant ( Z=‐5 .675 , P=0 .000);distinguish area of ROC curve both 0 .968 .Conclusion cPCa CC/C is correlated with Gleason score ,and can distinguish low risk from high risk tumors .