中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
Chinese Journal of Industrial Hygiene and Occupational Diseases
2015年
9期
695-697
,共3页
百草枯%中毒%肿瘤坏死因子%一氧化氮
百草枯%中毒%腫瘤壞死因子%一氧化氮
백초고%중독%종류배사인자%일양화담
Paraquat%Poisoning%Tumor necrosis factor%Nitric oxide
目的 探讨急性百草枯中毒(APP)患者血清中β-内啡呔(β-EP)、内皮素(ET)、肿瘤坏死因子(TNF)、一氧化氮(NO)等炎性细胞因子的临床意义.方法 测定26例急性百草枯中毒患者血清中β-EP、ET、TNF、NO的浓度,以患者亲属中20例健康自愿者的血清作为对照进行分析和比较.结果 26例急性百草枯中毒患者中治愈10例,死亡16例.生存组10例患者的β-EP,ET,TNF,NO血清浓度均于入院后即刻增高,第2天为高峰,之后缓慢下降,于9d后接近正常;死亡组16例患者入院时血清中β-EP、ET、TNF、NO浓度已明显增高,在治疗过程中仍然逐渐上升.与生存组比较,死亡组血清中β-EP、ET、TNF、NO浓度均明显增高,差异有统计学意义(P＜0.01).结论 急性百草枯中毒死亡患者血清中β-EP、ET、TNF、NO浓度明显高于生存患者,且持续上升,并处于高水平状态,预示病情严重.
目的 探討急性百草枯中毒(APP)患者血清中β-內啡呔(β-EP)、內皮素(ET)、腫瘤壞死因子(TNF)、一氧化氮(NO)等炎性細胞因子的臨床意義.方法 測定26例急性百草枯中毒患者血清中β-EP、ET、TNF、NO的濃度,以患者親屬中20例健康自願者的血清作為對照進行分析和比較.結果 26例急性百草枯中毒患者中治愈10例,死亡16例.生存組10例患者的β-EP,ET,TNF,NO血清濃度均于入院後即刻增高,第2天為高峰,之後緩慢下降,于9d後接近正常;死亡組16例患者入院時血清中β-EP、ET、TNF、NO濃度已明顯增高,在治療過程中仍然逐漸上升.與生存組比較,死亡組血清中β-EP、ET、TNF、NO濃度均明顯增高,差異有統計學意義(P＜0.01).結論 急性百草枯中毒死亡患者血清中β-EP、ET、TNF、NO濃度明顯高于生存患者,且持續上升,併處于高水平狀態,預示病情嚴重.
목적 탐토급성백초고중독(APP)환자혈청중β-내배태(β-EP)、내피소(ET)、종류배사인자(TNF)、일양화담(NO)등염성세포인자적림상의의.방법 측정26례급성백초고중독환자혈청중β-EP、ET、TNF、NO적농도,이환자친속중20례건강자원자적혈청작위대조진행분석화비교.결과 26례급성백초고중독환자중치유10례,사망16례.생존조10례환자적β-EP,ET,TNF,NO혈청농도균우입원후즉각증고,제2천위고봉,지후완만하강,우9d후접근정상;사망조16례환자입원시혈청중β-EP、ET、TNF、NO농도이명현증고,재치료과정중잉연축점상승.여생존조비교,사망조혈청중β-EP、ET、TNF、NO농도균명현증고,차이유통계학의의(P＜0.01).결론 급성백초고중독사망환자혈청중β-EP、ET、TNF、NO농도명현고우생존환자,차지속상승,병처우고수평상태,예시병정엄중.
Objective To investigate the clinical significance of dynamic changes in the serum inflammatory cell factors consisting of β-endorphin (β-EP),endothelins (ET),tumor necrosis factor (TNF),and nitric oxide (NO) after acute paraquat poisoning (APP).Methods The 26 patients with APP (as observation group) were treated and the serum levels of plasma β-EP,ET,TNF,and NO were measured simultaneously.The 20 healthy volunteers from relatives of the patients (as control group) were also included in the study and their serum levels of β-EP,ET,TNF,and NO were measured.Results In the 26 patients with APP,10 were cured and 16 died.The serum levels of β-EP,ET,NO,and TNF in the 10 cured patients increased significantly immediately after admission,reached the peak values on day 2,and then decreased gradually and returned to the normal ranges after day 9.The serum levels of β-EP,ET,NO,and TNF in the 16 dead patients increased significantly on admission and kept rising in the course of treatment.The dead patients had significantly increased serum levels of β-EP,ET,NO,and TNF compared with the cured patients (all P ＜0.01).Conclusion Compared with those in cured patients with APP,the serum levels of β-EP,ET,NO,and TNF in dead patients with APP are significantly higher,keep rising,and maintain at high levels,indicating a severe condition.
