CAJ | 학술논문

目的：观察斑蝥酸钠维生素 B6注射液在腹腔热灌注化疗治疗胃肠肿瘤恶性腹水中的临床疗效，以及对腹腔热灌注化疗不良反应的影响。方法对2010年4月-2012年6月收治的170例胃肠肿瘤恶性腹水病例按照治疗方法随机分入治疗组（斑蝥酸钠维生素 B6联合腹腔热灌注化疗）和对照组（单纯腹腔热灌注化疗）。比较两组的近期疗效、疾病进展期、总生存期、KPS 评分变化和不良反应。结果治疗组的近期有效率为71.1%，对照组为49.4%，两组间比较，差异有统计学意义（P=0.005）；两组治疗前后的 KPS 评分差异有统计学意义（P =0.016）。治疗组的中位生存期为12.62，对照组中位生存期为12.06，差异无统计学意义（P =0.065）。治疗组的中位疾病进展时间为6.47个月，对照组中位疾病进展时间为6.04个月，差异无统计学意义（P =0.179）。在不良反应中，消化道反应差异有统计学意义（P =0.016）；骨髓抑制，心脏毒性等差异无统计学意义（P ﹥0.05）。结论斑蝥酸钠维生素 B6注射液在腹腔热灌注化疗治疗恶性腹水中近期疗效好，有延长生存时间趋势，可减少不良反应，能提高生活质量。
목적：관찰반모산납유생소 B6주사액재복강열관주화료치료위장종류악성복수중적림상료효，이급대복강열관주화료불량반응적영향。방법대2010년4월-2012년6월수치적170례위장종류악성복수병례안조치료방법수궤분입치료조（반모산납유생소 B6연합복강열관주화료）화대조조（단순복강열관주화료）。비교량조적근기료효、질병진전기、총생존기、KPS 평분변화화불량반응。결과치료조적근기유효솔위71.1%，대조조위49.4%，량조간비교，차이유통계학의의（P=0.005）；량조치료전후적 KPS 평분차이유통계학의의（P =0.016）。치료조적중위생존기위12.62，대조조중위생존기위12.06，차이무통계학의의（P =0.065）。치료조적중위질병진전시간위6.47개월，대조조중위질병진전시간위6.04개월，차이무통계학의의（P =0.179）。재불량반응중，소화도반응차이유통계학의의（P =0.016）；골수억제，심장독성등차이무통계학의의（P ﹥0.05）。결론반모산납유생소 B6주사액재복강열관주화료치료악성복수중근기료효호，유연장생존시간추세，가감소불량반응，능제고생활질량。
Objective To observe the clinical efficacy on malignant ascites of gastrointestinal tumor treated with sodium cantharidinate and vitamin B6 injection and hyperthermic intraperitoneal chemotherapy and the impacts of hyperthermic intraperitoneal chemotherapy on adverse reactions. Methods One hundred and seventy cases of malignant ascites of gastrointestinal tumor were collected from April 2010 to June 2012 and randomized into a treatment group(the combined therapy of sodium cantharidinate and vitamin B6 injec-tion and hyperthermic intraperitoneal chemotherapy)and a control group(simple application of hyperthermic intraperitoneal chemotherapy. The short - term efficacy,disease progression,total survival span,KPS score and adverse reactions were compared between the two groups. Results The short - term effective rate was 71. 1% in the treatment group and was 49. 4% in the control group,indicating the significant difference in comparison(P = 0. 005). KPS score was different significantly before and after treatment in the two groups(P= 0. 016). The medium survival span was 12. 62 in the treatment group and was 12. 06 in the control group, indicating the significant difference(P = 0. 065). The medium disease progression time was 6. 47 months in the treatment group and was 6. 04 months in the control group. Regarding the adverse reactions,the digestive reaction was different significantly(P = 0. 016). The differences in bone marrow inhibition and cardiac toxici-ty were not significant(P ﹥ 0. 05). Conclusion Sodium cantharidinate and vitamin B6 injection achieves the good short - term efficacy,prolongs the life span in tendency,reduces adverse reactions and improves the life of activity in the treatment of malignant ascites with hyperthermic intraperitoneal chemotherapy.