CAJ | 학술논문

目的：利用轻质子磁共振波谱技术（1 H‐MRS）评价绝经后2型糖尿病（T2DM ）腰椎骨髓脂质含量（MLC）变化规律。方法收集绝经后T2DM患者（n＝30）及年龄匹配的健康受试者（n＝20）行L3椎体1 H‐MRS扫描以计算MLC值及双能X线骨密度测定仪测定L1～L4椎体骨密度（BMD）。测定受检者空腹血糖（FPG）、糖化血红蛋白（HbA1c）及胰岛素（FINS）水平。结果 T2DM组BMD（1．180±0．198）g／cm2与健康对照组BMD（1．113±0．187）g／cm2无统计学差异。T2DM组MLC（76．3±18．3）％明显高于正常受试者（65．7±14．0）％（ P ＜0．001），校正受试者 T2DM 病程、体质分数、FINS及BMD混杂因素，T2DM组MLC值仍高于健康受试者（ P ＝0．020）。Logistic逐步回归分析表明，MLC是T2DM患者的负性影响因素（OR＝2．031，P ＝0．008）。结论绝经后T2DM患者骨髓脂肪增高，1 H‐MRS测定MLC可作为T2DM随诊方法之一。
목적：이용경질자자공진파보기술（1 H‐MRS）평개절경후2형당뇨병（T2DM ）요추골수지질함량（MLC）변화규률。방법수집절경후T2DM환자（n＝30）급년령필배적건강수시자（n＝20）행L3추체1 H‐MRS소묘이계산MLC치급쌍능X선골밀도측정의측정L1～L4추체골밀도（BMD）。측정수검자공복혈당（FPG）、당화혈홍단백（HbA1c）급이도소（FINS）수평。결과 T2DM조BMD（1．180±0．198）g／cm2여건강대조조BMD（1．113±0．187）g／cm2무통계학차이。T2DM조MLC（76．3±18．3）％명현고우정상수시자（65．7±14．0）％（ P ＜0．001），교정수시자 T2DM 병정、체질분수、FINS급BMD혼잡인소，T2DM조MLC치잉고우건강수시자（ P ＝0．020）。Logistic축보회귀분석표명，MLC시T2DM환자적부성영향인소（OR＝2．031，P ＝0．008）。결론절경후T2DM환자골수지방증고，1 H‐MRS측정MLC가작위T2DM수진방법지일。
Objective To explore the changing process of vertebral marrow lipid content (MLC) using MR spectroscopy (MRS) in postmenopausal females with type 2 diabetes (T2DM ) .Methods T2DM Patients (n= 30) and age‐matched healthy controls (n=20) underwent MRS and DXA scanning to determine MLC and BMD values .Blood glucose (FPG) , hemoglobin A1c (HbA1c) and fasting insulin (FINS) were measured after fasting for 12 h .Results There was no signifi‐cant difference in BMD between T2DM patients (1 .180 ± 0 .198) g/cm2 and controls (1 .113 ± 0 .187) g/cm2 .T2DM pa‐tients had higher FF (76 .3 ± 18 .3)% than that of controls (65 .7 ± 14 .0% ) ( P <0 .001) .After adjustment for disease duration ,BMI ,FINS and BMD ,the difference between groups remained significantly .Logistic regression analysis re‐vealed that MLC was independent indicator for T2DM (OR=2 .031 ,P=0 .008) .Conclusion Postmenopausal T2DM pa‐tients have higher marrow fat content of vertebral bodies .MRS may be a useful tool to detect MLC for the follow‐up of T2DM patients .