CAJ | 학술논문

目的：分析灼口综合征（BMS）患者的焦虑及抑郁症状，探讨 BMS 的危险因素。方法：以口腔医院黏膜科诊断为 BMS 的147名患者作为病例组；以性别及年龄匹配的正常人群140人作为对照组，进行病例对照研究。采用自制的 BMS 危险因素问卷收集病例组和对照组的全身情况和药物史；采用焦虑自评量表和抑郁自评量表评价试验组和对照组的焦虑抑郁症状。统计方法包括 t 检验，χ2检验和 logistic 回归分析。结果：病例组焦虑症状评分高于对照组[（44.4±9.9）vs.（35.7±6.2）]，病例组抑郁症状评分高于对照组[（48.1±11.6）vs.（37.5±8.9）]，差异有统计学意义（P ＜0.001）。BMS 的危险因素为受教育程度低（OR ＝1.91，95％CI：1.04～3.49）、缺血性脑卒中史（OR ＝4.46，95％CI：1.87～10.95）、焦虑症状（OR ＝8.12，95％CI：2.60～25.37）及抑郁症状（OR ＝2.5795％CI：1.26～5.27）。结论：BMS是多因素导致的疾病，其中较低的受教育水平、缺血性脑卒中史、焦虑及抑郁症状是 BMS 的主要危险因素，对 BMS 的治疗应联合精神科，加强心理治疗手段。
목적：분석작구종합정（BMS）환자적초필급억욱증상，탐토 BMS 적위험인소。방법：이구강의원점막과진단위 BMS 적147명환자작위병례조；이성별급년령필배적정상인군140인작위대조조，진행병례대조연구。채용자제적 BMS 위험인소문권수집병례조화대조조적전신정황화약물사；채용초필자평량표화억욱자평량표평개시험조화대조조적초필억욱증상。통계방법포괄 t 검험，χ2검험화 logistic 회귀분석。결과：병례조초필증상평분고우대조조[（44.4±9.9）vs.（35.7±6.2）]，병례조억욱증상평분고우대조조[（48.1±11.6）vs.（37.5±8.9）]，차이유통계학의의（P ＜0.001）。BMS 적위험인소위수교육정도저（OR ＝1.91，95％CI：1.04～3.49）、결혈성뇌졸중사（OR ＝4.46，95％CI：1.87～10.95）、초필증상（OR ＝8.12，95％CI：2.60～25.37）급억욱증상（OR ＝2.5795％CI：1.26～5.27）。결론：BMS시다인소도치적질병，기중교저적수교육수평、결혈성뇌졸중사、초필급억욱증상시 BMS 적주요위험인소，대 BMS 적치료응연합정신과，가강심리치료수단。
Objective:To evaluate the anxiety and depression symptoms of burning mouth syndrome (BMS), and to explore risk factors to BMS.Method:In this case-control study,147 patients with BMS and 140 sex-and age-matched healthy volunteers were recruited.Three questionnaires were used to collect information of psychical and mental condition.The Self-Rating Anxiety Scale (SAS)and Self-Rating Depression Scale (SDS)were applied to evaluate symptoms of anxiety and depression.The scores of SAS and SDS were statistically analyzed by t-test.The risk factors of BMS were statistically analyzed by Chi-square test and logistic regression analysis.Result:The scores of SAS and SDS were higher in the patients with BMS than in the controls [SAS:(44.4 ±9.9)vs. (35.7 ±6.2);SDS:(48.1 ±11.6)vs.(37.5 ±8.9)].The risk factors of BMS included ischemic stroke (OR =4.46,95%CI:1.87 -10.95),low level of education (OR =1.91,95%CI:1.04 -3.49),anxiety symptom (OR =8.12,95%CI:2.60 -25.37)and depression symptom (OR =2.57,95%CI:1.26 -5.27).Conclusion:BMS is a multi-factorial disease.It indicates that ischemic stroke,lower level of education,anxiety symptom and depression symptom are the risk factors of BMS.A positive association could be established between psychological alterations and BMS.According to these findings it can be assumed that mental factors should be taking into account in the etiologyof BMS.It should be advocated to treat BMS patients by psychotherapy.