中国心理卫生杂志
中國心理衛生雜誌
중국심리위생잡지
Chinese Mental Health Journal
2015年
10期
733-737
,共5页
陈大春%李艳丽%杨可冰%王宁%聂鹰%张进国%张向阳
陳大春%李豔麗%楊可冰%王寧%聶鷹%張進國%張嚮暘
진대춘%리염려%양가빙%왕저%섭응%장진국%장향양
首发精神分裂症%听觉感觉门控 P50%认知功能
首髮精神分裂癥%聽覺感覺門控 P50%認知功能
수발정신분렬증%은각감각문공 P50%인지공능
first-episode schizophrenia%auditory gating P50%cognitive function
目的：探讨首发精神分裂症患者的认知功能与感觉门控 P50关系。方法：使用美国精神障碍诊断与统计手册第4版（DSM-Ⅳ）轴Ⅰ临床定式检查诊断首发精神分裂症住院患者106例，86名来自社区并且年龄、性别、受教育程度与患者匹配正常对照，采用听觉条件（S1）－测试（S2）刺激范式对所有研究对象进行 P50检测，检测指标为 S1、S2潜伏期和波幅，S2／S1抑制率，（Sl-S2）差值。根据抑制比，将 S2／S1≤0.4定义为抑制比正常，S2／S1＞0.4定义为抑制比异常。采用精神分裂症认知功能成套测验中文版（MCCB）评估所有对象认知功能。结果：精神分裂症患者的 S1潜伏期、S2潜伏期长于正常对照组， S1波幅、（S1-S2）波幅低于对照组，S2／S1抑制率显著高于对照组（均 P ＜0.01）；精神分裂症患者的MCCB 各维度得分均低于对照组（均 P ＜0.05）。精神分裂症患者 P50抑制率正常、异常者的 MCCB 分测验评分及总分差异无统计学意义（均 P ＞0.05）。多元逐步回归分析显示 P50抑制率、（S1-S2）波幅与MCCB 评分的相关性无统计学意义（均 P ＞0.05）。结论：首发精神分裂症患者的认知功能可能与感觉门控 P50抑制缺陷无关联。
目的：探討首髮精神分裂癥患者的認知功能與感覺門控 P50關繫。方法：使用美國精神障礙診斷與統計手冊第4版（DSM-Ⅳ）軸Ⅰ臨床定式檢查診斷首髮精神分裂癥住院患者106例，86名來自社區併且年齡、性彆、受教育程度與患者匹配正常對照，採用聽覺條件（S1）－測試（S2）刺激範式對所有研究對象進行 P50檢測，檢測指標為 S1、S2潛伏期和波幅，S2／S1抑製率，（Sl-S2）差值。根據抑製比，將 S2／S1≤0.4定義為抑製比正常，S2／S1＞0.4定義為抑製比異常。採用精神分裂癥認知功能成套測驗中文版（MCCB）評估所有對象認知功能。結果：精神分裂癥患者的 S1潛伏期、S2潛伏期長于正常對照組， S1波幅、（S1-S2）波幅低于對照組，S2／S1抑製率顯著高于對照組（均 P ＜0.01）；精神分裂癥患者的MCCB 各維度得分均低于對照組（均 P ＜0.05）。精神分裂癥患者 P50抑製率正常、異常者的 MCCB 分測驗評分及總分差異無統計學意義（均 P ＞0.05）。多元逐步迴歸分析顯示 P50抑製率、（S1-S2）波幅與MCCB 評分的相關性無統計學意義（均 P ＞0.05）。結論：首髮精神分裂癥患者的認知功能可能與感覺門控 P50抑製缺陷無關聯。
목적：탐토수발정신분렬증환자적인지공능여감각문공 P50관계。방법：사용미국정신장애진단여통계수책제4판（DSM-Ⅳ）축Ⅰ림상정식검사진단수발정신분렬증주원환자106례，86명래자사구병차년령、성별、수교육정도여환자필배정상대조，채용은각조건（S1）－측시（S2）자격범식대소유연구대상진행 P50검측，검측지표위 S1、S2잠복기화파폭，S2／S1억제솔，（Sl-S2）차치。근거억제비，장 S2／S1≤0.4정의위억제비정상，S2／S1＞0.4정의위억제비이상。채용정신분렬증인지공능성투측험중문판（MCCB）평고소유대상인지공능。결과：정신분렬증환자적 S1잠복기、S2잠복기장우정상대조조， S1파폭、（S1-S2）파폭저우대조조，S2／S1억제솔현저고우대조조（균 P ＜0.01）；정신분렬증환자적MCCB 각유도득분균저우대조조（균 P ＜0.05）。정신분렬증환자 P50억제솔정상、이상자적 MCCB 분측험평분급총분차이무통계학의의（균 P ＞0.05）。다원축보회귀분석현시 P50억제솔、（S1-S2）파폭여MCCB 평분적상관성무통계학의의（균 P ＞0.05）。결론：수발정신분렬증환자적인지공능가능여감각문공 P50억제결함무관련。
Objective:To explore the relation of cognitive function correlates to P50 sensory gating in patients with schizophrenia.Methods:Totally 106 patients with drug-na¨ive first-episode schizophrenia and 86 healthy con-trol subjects matched for age,sex and education were recruited.All patients met the Diagnostic and Statistical Man-ual of Mental Disorders,Fourth Edition (DSM-IV)criteria for schizophrenia.Their cognitive function were assessed with the MATRICS Consensus Cognitive Battery (MCCB).The P50 auditory gating potential were recorded in all subjects using conditioning-testing stimulus paradigm and stimulus train paradigm.The P50 components were meas-ured in S1 S2 latency,S1 S2 amplitude and P50 suppression ratios.Results:Compared with the controls subjects, the patients with schizophrenia had significantly longer S1[60.8 ±7.8)ms vs.(56.3 ±7.0)ms,P <0.05]S2 la-tency [(59.1 ±10.2)ms vs.(55.7 ±10.7)ms,P <0.05],lower S1 amplitude [(2.8 ±1.8)μV vs.(3.5 ±1.6)μV,P <0.05],less amplitude difference (S1-S2)[(1.5 ±1.8)μV vs.(2.2 ±1.4)μV,P <0.05]and higher P50 suppression ratios (S2 /S1 )[(59.7 ±65.6)vs.(37.6 ±30.0),P <0.05].Schizophrenia patients had lower score than control subjects in all cognitive domains of MCCB (Ps <0.05).No differences in neurocognitive performance were found between subjects in the normal P50 ratio and the abnormal in healthy controls or patients with schizo-phrenia (Ps >0.05).No significant correlation was found between P50 gating measures (P50 ratio and P50 ampli-tude difference)and neuropsychological measures in MCCB scores (Ps >0.05).Conclusion:There may be no as-sociation between P50 deficits and cognitive measures in patients with drug-na¨ive first-episode schizophrenia.
