CAJ | 학술논문

目的：研究济川煎及以不同功效拆方对小鼠肠蠕动的影响。方法按济川煎组方中中药功效拆方为温肾润肠组（肉苁蓉、牛膝、当归）、降浊组（泽泻、枳壳）及升清组（升麻），考察不同组方对便秘模型小鼠小肠碳末推进、排便实验、大小肠含水量的影响。结果济川煎全方及降浊组与模型组相比，能显著增加模型小鼠炭末推进率（P＜0.01）；济川煎全方及温肾润肠组与模型组相比，能显著增加模型小鼠小肠含水量（P＜0.01）及大肠含水量（P＜0.05）；济川煎全方明显增加模型小鼠4h排便粒数及4h排便重量，与模型组相比（P＜0.05）。结论温肾润肠药物能显著增加肠道含水量，降浊药物能显著促进小肠的推进功能，全方能显著促进排便。
목적：연구제천전급이불동공효탁방대소서장연동적영향。방법안제천전조방중중약공효탁방위온신윤장조（육종용、우슬、당귀）、강탁조（택사、지각）급승청조（승마），고찰불동조방대편비모형소서소장탄말추진、배편실험、대소장함수량적영향。결과제천전전방급강탁조여모형조상비，능현저증가모형소서탄말추진솔（P＜0.01）；제천전전방급온신윤장조여모형조상비，능현저증가모형소서소장함수량（P＜0.01）급대장함수량（P＜0.05）；제천전전방명현증가모형소서4h배편립수급4h배편중량，여모형조상비（P＜0.05）。결론온신윤장약물능현저증가장도함수량，강탁약물능현저촉진소장적추진공능，전방능현저촉진배편。
ABSTRACT:OBJECTIVE To study the effect of the disassembled prescriptions in Jichuanjian on peristalsis in mice.METHODS Jichuanjian prescription was divided into Wenshenrunchang group、Jiangzhuo group and Shengqing group according to Chinese medicine efficacy.Then they were detected on the percentage index promoted by carbon powder ,defecation condition and intestinal moisture content.RESULTS The percentages index promoted by carbon powder in Jichuanjian group and Jiangzhuo group were higher than those of control group ( P<0.05 ).The intestinal moisture contents in Jichuanjian group and Wenshenrunchang group were higher than those of control group ( P<0.05 ).Weight of defecation and grain number of defecation in Jichuanjian group were higher than those of con -trol group ( P<0.05 ).CONCLUSION Wenshenrunchang group can significantly increase intestinal moisture con-tent.Jiangzhuo group can significantly improve the function of intestine propulsion.Jichuanjian can significantly im-prove defecation.