中外医学研究
中外醫學研究
중외의학연구
Chinese and Foreign Medical Research
2015年
29期
7-8,9
,共3页
非小细胞肺癌%缺口末端标记法%凋亡指数
非小細胞肺癌%缺口末耑標記法%凋亡指數
비소세포폐암%결구말단표기법%조망지수
NSCLC%TUNEL%AI
目的：检测非小细胞肺癌(non-small cell lung cancer，NSCLC)组织中肿瘤细胞凋亡水平，计算凋亡指数(apoptosis index，AI)，并探讨其与临床病理特征的关系。方法：应用缺口末端标记法(terminal-deoxynucleoitidyl transferase mediated nick end labeling，TUNEL)检测57例NSCLC组织和19例癌旁肺组织的细胞凋亡水平，并分析其与淋巴结转移、肿瘤分期、组织学类型等临床病理特征的相关性。结果：NSCLC组织AI低于癌旁肺组织(P<0.001)；有淋巴结转移组AI高于无转移组(P<0.001)；Ⅰ、Ⅱ期组AI高于Ⅲ、Ⅳ组(P<0.001)。结论：NSCLC组织AI低于癌旁肺组织，且随着肿瘤分期的增高而下降，AI与肿瘤是否存在淋巴结转移有关，细胞凋亡的减少可能是NSCLC发生、发展过程的重要机制之一，但作为判断患者预后的新型指标，需结合多方面的因素进行分析。
目的：檢測非小細胞肺癌(non-small cell lung cancer，NSCLC)組織中腫瘤細胞凋亡水平，計算凋亡指數(apoptosis index，AI)，併探討其與臨床病理特徵的關繫。方法：應用缺口末耑標記法(terminal-deoxynucleoitidyl transferase mediated nick end labeling，TUNEL)檢測57例NSCLC組織和19例癌徬肺組織的細胞凋亡水平，併分析其與淋巴結轉移、腫瘤分期、組織學類型等臨床病理特徵的相關性。結果：NSCLC組織AI低于癌徬肺組織(P<0.001)；有淋巴結轉移組AI高于無轉移組(P<0.001)；Ⅰ、Ⅱ期組AI高于Ⅲ、Ⅳ組(P<0.001)。結論：NSCLC組織AI低于癌徬肺組織，且隨著腫瘤分期的增高而下降，AI與腫瘤是否存在淋巴結轉移有關，細胞凋亡的減少可能是NSCLC髮生、髮展過程的重要機製之一，但作為判斷患者預後的新型指標，需結閤多方麵的因素進行分析。
목적：검측비소세포폐암(non-small cell lung cancer，NSCLC)조직중종류세포조망수평，계산조망지수(apoptosis index，AI)，병탐토기여림상병리특정적관계。방법：응용결구말단표기법(terminal-deoxynucleoitidyl transferase mediated nick end labeling，TUNEL)검측57례NSCLC조직화19례암방폐조직적세포조망수평，병분석기여림파결전이、종류분기、조직학류형등림상병리특정적상관성。결과：NSCLC조직AI저우암방폐조직(P<0.001)；유림파결전이조AI고우무전이조(P<0.001)；Ⅰ、Ⅱ기조AI고우Ⅲ、Ⅳ조(P<0.001)。결론：NSCLC조직AI저우암방폐조직，차수착종류분기적증고이하강，AI여종류시부존재림파결전이유관，세포조망적감소가능시NSCLC발생、발전과정적중요궤제지일，단작위판단환자예후적신형지표，수결합다방면적인소진행분석。
Objective:To detect the level of tumor cell apoptosis in NSCLC,and investigate the relationship of apoptosis index(AI) with clinicopathological features.Method:The level of 57 cases of NSCLC and 19 cases of cell apoptosis were evaluated by TUNEL,and analyzed the relationship with the clinicopathological features such as lymph node metastasis,tumor stage,histological type.Result:The level of AI in NSCLC tissues was statistically lower than that in adjacent non-cancerous lung tissues(P<0.001).The AI of With lymph node metastasis group was higher than that in non transfer group(P<0.001),the Ⅰ and Ⅱ group were higher than the Ⅲ and Ⅳ group.Conclusion:The level of AI in NSCLC tissues was statistically lower than that in adjacent non-cancerous lung tissues,and it was correlated with lymph node metastasis,TNM stage.Cell apoptosis may be an important mechanism for the development of NSCLC,but could it be a prognostic indicator,it may need more factors to evaluate.
