中外医学研究
中外醫學研究
중외의학연구
Chinese and Foreign Medical Research
2015年
29期
1-3,4
,共4页
口腔支架%头颈部放疗%舌%Meta分析
口腔支架%頭頸部放療%舌%Meta分析
구강지가%두경부방료%설%Meta분석
Intraoral stents%Head and neck radiotherapy%Tongue%Meta analysis
目的：评估口腔支架在头颈部放疗中保护舌的效果。方法：计算机检索Embase、Pubmed、Google scholar英文数据库和中国知网、万方、维普等中文数据库，筛选关于口腔支架在头颈部肿瘤放疗运用的相关随机对照试验，并用RevMan 5.2软件进行Meta分析。结果：最终纳入5个RCT，共203例患者。Meta分析结果示：口腔支架在头颈放疗中降低舌体平均照射剂量[MD=-11.89，95%CI=(-15.48，-8.30)，P<0.00001]，降低味觉损伤率[OR=0.12，95%CI=(0.05，0.28)，P<0.00001]以及降低舌黏膜毒性反应率[OR=0.09，95%CI=(0.02，0.37)， P=0.00009]，差异均有统计学意义。结论：口腔支架在头颈部放疗中能有效保护舌体组织，基于纳入研究的局限性与可能存在的偏倚，需要更多严谨的大样本的研究予以论证。
目的：評估口腔支架在頭頸部放療中保護舌的效果。方法：計算機檢索Embase、Pubmed、Google scholar英文數據庫和中國知網、萬方、維普等中文數據庫，篩選關于口腔支架在頭頸部腫瘤放療運用的相關隨機對照試驗，併用RevMan 5.2軟件進行Meta分析。結果：最終納入5箇RCT，共203例患者。Meta分析結果示：口腔支架在頭頸放療中降低舌體平均照射劑量[MD=-11.89，95%CI=(-15.48，-8.30)，P<0.00001]，降低味覺損傷率[OR=0.12，95%CI=(0.05，0.28)，P<0.00001]以及降低舌黏膜毒性反應率[OR=0.09，95%CI=(0.02，0.37)， P=0.00009]，差異均有統計學意義。結論：口腔支架在頭頸部放療中能有效保護舌體組織，基于納入研究的跼限性與可能存在的偏倚，需要更多嚴謹的大樣本的研究予以論證。
목적：평고구강지가재두경부방료중보호설적효과。방법：계산궤검색Embase、Pubmed、Google scholar영문수거고화중국지망、만방、유보등중문수거고，사선관우구강지가재두경부종류방료운용적상관수궤대조시험，병용RevMan 5.2연건진행Meta분석。결과：최종납입5개RCT，공203례환자。Meta분석결과시：구강지가재두경방료중강저설체평균조사제량[MD=-11.89，95%CI=(-15.48，-8.30)，P<0.00001]，강저미각손상솔[OR=0.12，95%CI=(0.05，0.28)，P<0.00001]이급강저설점막독성반응솔[OR=0.09，95%CI=(0.02，0.37)， P=0.00009]，차이균유통계학의의。결론：구강지가재두경부방료중능유효보호설체조직，기우납입연구적국한성여가능존재적편의，수요경다엄근적대양본적연구여이론증。
Objective:To evaluate the efficacy of protection of the tongue effect in the intraoral stents in head and neck radiotherapy. Method:Electronic databases of Embase,PubMed and Google scholar in English and CNKI,ChinaInfo,VIP in Chinese were searched,and the randomized controlled trials about Intraoral stent in head and neck cancer radiotherapy were selected.Meta analysis were performed by using RevMan 5.2 software.Result:Five RCTs involving 203 patients were included Meta analysis.Results of Meta analyses showed that:Intraoral Stents reduced the average tongue body exposure dose in head and neck radiation therapy[MD=-11.89,95%CI=(-15.48,-8.30),P<0.00001],reduced the taste damage rate[OR=0.12,95%CI=0.05,0.28,P<0.00001],and reduced the tongue mucosa toxicity reaction rate[OR=0.09,95%CI=(0.02,0.37),P=0.00009], The differences were statistically significant.Conclusion:Intraoral stent in head and neck radiotherapy can effectively protect the tongue body tissue, based on the research limitations and possible bias,a study of large sample of need more rigorous reasoning.
