中国当代医药
中國噹代醫藥
중국당대의약
China Modern Medicine
2015年
26期
18-21
,共4页
碳青霉烯类抗生素%碳青霉烯酶%细菌%耐药机制
碳青黴烯類抗生素%碳青黴烯酶%細菌%耐藥機製
탄청매희류항생소%탄청매희매%세균%내약궤제
Carbapenem antibiotics%Carbapenemasese%Bacterium%Resistance mechanism
碳青霉烯类抗生素是目前临床上抗菌谱最广、抗菌活性最强的非典型β-内酰胺类抗生素，然而随着碳青霉烯类药物在临床上的广泛应用，细菌对其耐药性不断增加，给临床抗感染治疗带来了新的挑战。为延缓其耐药现象的发展，本文从产生碳青霉烯酶、结合位点改变、外膜孔蛋白缺失或减少、主动外排泵过度表达、细菌生物膜系统等5个方面介绍了碳青霉烯类抗生素的耐药机制，为进行新的药物设计与开发提供依据，同时为临床医师谨慎、合理地应用碳青霉烯类药物提供参考。
碳青黴烯類抗生素是目前臨床上抗菌譜最廣、抗菌活性最彊的非典型β-內酰胺類抗生素，然而隨著碳青黴烯類藥物在臨床上的廣汎應用，細菌對其耐藥性不斷增加，給臨床抗感染治療帶來瞭新的挑戰。為延緩其耐藥現象的髮展，本文從產生碳青黴烯酶、結閤位點改變、外膜孔蛋白缺失或減少、主動外排泵過度錶達、細菌生物膜繫統等5箇方麵介紹瞭碳青黴烯類抗生素的耐藥機製，為進行新的藥物設計與開髮提供依據，同時為臨床醫師謹慎、閤理地應用碳青黴烯類藥物提供參攷。
탄청매희류항생소시목전림상상항균보최엄、항균활성최강적비전형β-내선알류항생소，연이수착탄청매희류약물재림상상적엄범응용，세균대기내약성불단증가，급림상항감염치료대래료신적도전。위연완기내약현상적발전，본문종산생탄청매희매、결합위점개변、외막공단백결실혹감소、주동외배빙과도표체、세균생물막계통등5개방면개소료탄청매희류항생소적내약궤제，위진행신적약물설계여개발제공의거，동시위림상의사근신、합리지응용탄청매희류약물제공삼고。
Carbapenems are a class of β-lactam antibiotics with a broad spectrum and the strongest of antibacterial activity in currently clinic.However,with the wide-spread use of carbapenems in the clinical, the bacterial resistance to antibiotics is increasing,which has brought new challenges to the clinical treatment of infection.To delay the develop-ment of drug resistance,this text researched five aspects about the mechanisms of carbapenem resistant,which are as fol-lows:the production of carbapenemases,altered binding site,the loss or reduce of outer membrane protein,overexpression of efflux pump system,bacterial biofilm system in this article.To can provide the basis for the design and development of new drugs,and provide reference for the clinicians to use the drug carefully and reasonably.
