CAJ | 학술논문

目的：探讨免疫毒素设计的新思路以及制备方法。方法通过分析传统免疫毒素的结构，总结免疫毒素的研究进展，以及本课题组的实验探究等方法来进行免疫毒素的设计与制备。结果免疫毒素可通过多种方法来进行优化设计，常用的制备方法有化学偶联法及基因工程融合法。结论免疫毒素作为恶性肿瘤的靶向治疗已取得一定的发展，因此对免疫毒素进行优化设计显现出极大的应用前景。
목적：탐토면역독소설계적신사로이급제비방법。방법통과분석전통면역독소적결구，총결면역독소적연구진전，이급본과제조적실험탐구등방법래진행면역독소적설계여제비。결과면역독소가통과다충방법래진행우화설계，상용적제비방법유화학우련법급기인공정융합법。결론면역독소작위악성종류적파향치료이취득일정적발전，인차대면역독소진행우화설계현현출겁대적응용전경。
ABSTRACT:OBJECTIVE To explore new designing approaches and preparation methods of immunotox-ins.METHODS To study the design and preparation methods by analysing the traditional structure of the immuno -toxins,summarizing the research development of immunotoxins ,as well as our own experiment studying.RESULTS Immunotoxins can be optimal designed by various methods which include the chemical coupling method and genetic engineering fusion.CONCLUSION Immunotoxins as a new targeted drug for cancer therapy has made a certain de-velopment.The optimal design of immunotoxins displays large application perspective.