眼科学报（英文版）
眼科學報（英文版）
안과학보（영문판）
Eye Science
2015年
3期
101-105
,共5页
翼状胬肉%显微手术%自体角膜缘干细胞移植%远期效果
翼狀胬肉%顯微手術%自體角膜緣榦細胞移植%遠期效果
익상노육%현미수술%자체각막연간세포이식%원기효과
pterygium%microscopic surgery%autologous corneal limbal stem cell transplantation%long-term efficacy
目的：探讨胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉的远期效果。方法：2003年12月－2008年12月在我院就诊的原发性翼状胬肉患者55例57眼，均采用胬肉切除联合自体角膜缘干细胞移植治疗，术后随访2～8年，平均5．3年。观察创面愈合情况、治疗效果和并发症情况。结果：术后早期患者均有不同程度的充血、水肿和异物感，3～5d后症状逐渐减轻，一周左右完全消失。角膜创面完全上皮化时间为4～7 d，平均4．83 d。术后有持续性眼表刺激症状者7例，术后残留纤维组织者1例，角膜浅层瘢痕者4例。术后随访2～8年，平均5．3年，复发8例8眼（复发率13．11％）。术后1年时复查OSDI评分，所有患者较术前评分均有不同程度的降低，与术前相比，两组评分和构成比差异有统计学意义（P＜0．05）。术后5年时复查OSDI评分较1年前稍有降低，但差异没有统计学意义（P＞0．05）。术后1、5年时泪液基础分泌[（12．95±4．03）mm，（12．68±4．77）mm]和泪膜破裂时间[（10．55±4．13）s，（10．03±4．64）s]较术前[（9．48±3．34）mm，（8．14±3．57）s]明显改善，差异有统计学意义（P＜0．05）。结论：应用胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉，术后早期症状轻、消失快，远期复发少，效果良好。眼科学报2015：30：101－105．
目的：探討胬肉切除聯閤自體角膜緣榦細胞移植治療翼狀胬肉的遠期效果。方法：2003年12月－2008年12月在我院就診的原髮性翼狀胬肉患者55例57眼，均採用胬肉切除聯閤自體角膜緣榦細胞移植治療，術後隨訪2～8年，平均5．3年。觀察創麵愈閤情況、治療效果和併髮癥情況。結果：術後早期患者均有不同程度的充血、水腫和異物感，3～5d後癥狀逐漸減輕，一週左右完全消失。角膜創麵完全上皮化時間為4～7 d，平均4．83 d。術後有持續性眼錶刺激癥狀者7例，術後殘留纖維組織者1例，角膜淺層瘢痕者4例。術後隨訪2～8年，平均5．3年，複髮8例8眼（複髮率13．11％）。術後1年時複查OSDI評分，所有患者較術前評分均有不同程度的降低，與術前相比，兩組評分和構成比差異有統計學意義（P＜0．05）。術後5年時複查OSDI評分較1年前稍有降低，但差異沒有統計學意義（P＞0．05）。術後1、5年時淚液基礎分泌[（12．95±4．03）mm，（12．68±4．77）mm]和淚膜破裂時間[（10．55±4．13）s，（10．03±4．64）s]較術前[（9．48±3．34）mm，（8．14±3．57）s]明顯改善，差異有統計學意義（P＜0．05）。結論：應用胬肉切除聯閤自體角膜緣榦細胞移植治療翼狀胬肉，術後早期癥狀輕、消失快，遠期複髮少，效果良好。眼科學報2015：30：101－105．
목적：탐토노육절제연합자체각막연간세포이식치료익상노육적원기효과。방법：2003년12월－2008년12월재아원취진적원발성익상노육환자55례57안，균채용노육절제연합자체각막연간세포이식치료，술후수방2～8년，평균5．3년。관찰창면유합정황、치료효과화병발증정황。결과：술후조기환자균유불동정도적충혈、수종화이물감，3～5d후증상축점감경，일주좌우완전소실。각막창면완전상피화시간위4～7 d，평균4．83 d。술후유지속성안표자격증상자7례，술후잔류섬유조직자1례，각막천층반흔자4례。술후수방2～8년，평균5．3년，복발8례8안（복발솔13．11％）。술후1년시복사OSDI평분，소유환자교술전평분균유불동정도적강저，여술전상비，량조평분화구성비차이유통계학의의（P＜0．05）。술후5년시복사OSDI평분교1년전초유강저，단차이몰유통계학의의（P＞0．05）。술후1、5년시루액기출분비[（12．95±4．03）mm，（12．68±4．77）mm]화루막파렬시간[（10．55±4．13）s，（10．03±4．64）s]교술전[（9．48±3．34）mm，（8．14±3．57）s]명현개선，차이유통계학의의（P＜0．05）。결론：응용노육절제연합자체각막연간세포이식치료익상노육，술후조기증상경、소실쾌，원기복발소，효과량호。안과학보2015：30：101－105．
Purpose:To evaluate the long-term efficacy of pterygium excision combined with autologous corneal lim-bal stem cell transplantation in the treatment of pterygium. Methods: Fifty five patients (57 eyes) diagnosed with primary pterygium undergoing pterygium excision combined with autologous corneal limbal stem cell transplantation between December 2003 and December 2008 were enrolled in this study. Postoperative follow-up endured for 2-8 years , 5.3 years on average. The wound healing, clinical efficacy and postoperative complications were observed. Results: During early stage after surgery, all patients presented with varying degree of hyperemia, edema and sense of foreign body, which were gradually mitigated 3-5 d later and completely recovered in ap-proximately 1 week. The corneal wound was completely epithelized within 4-7 d , 4.83 d on average. Sev-en patients had persistent ocular surface irritation symptoms after surgery , one case had residual fibrous tissues and four patients developed superficial corneal scars. Postoperative follow-up endured for 2-8 years, 5.3 years on average. Eight patients (8 eyes) recurred with a recurrence rate of 13.11%. In all pa-tients, postoperative OSDI score was significantly decreased at 1-year reexamination. OSDI score and con-stitution ratio significantly differed between two groups (both P<0.05). At postoperative 5 years, OSDI score was slightly lower compared with that in last year with no statistical significance (P>0.05). At post-operative 1- and 5-year, basic tear secretion was (12.95 ±4.03) mm and (12.68 ±4.77) mm, tear film break-up time was (10.55±4.13) s and (10.03±4.64) s. Both indexes were significantly improved com-pared with (9.48±3.34) mm and (8.14±3.57) s before surgery (all P<0.05). Conclusion:Pterygium excision combined with autologous corneal limbal stem cell transplantation is an ef-ficacious treatment of pterygium with mild postoperative symptoms, rapid recovery, low long-term recur-rence rate and high efficacy.
