CAJ | 학술논문

目的：研究高脂血症性急性胰腺炎患者D-二聚体和凝血指标的变化与血钙的关系。方法选择2013年1月至2014年12月高脂血症性急性胰腺炎患者64例。根据疾病严重程度分为轻度胰腺炎组和中度胰腺炎组。检测凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、凝血酶时间和D-二聚体，并同时检测血钙。比较两组上述指标的不同及其和血钙的关系。结果轻度胰腺炎组的凝血酶原时间、纤维蛋白原、D-二聚体均明显低于中度胰腺炎组而血钙则相反。凝血酶原时间、纤维蛋白原、D-二聚体与血钙均为负相关(r分别为-0.338、-0.254和-0.248，P分别为0.006、0.042和0.048)。结论高脂血症性急性胰腺炎患者的凝血酶原时间、纤维蛋白原、D-二聚体均随病情加重而升高。而血钙下降可能与凝血酶原时间、纤维蛋白原、D-二聚体相关。
목적：연구고지혈증성급성이선염환자D-이취체화응혈지표적변화여혈개적관계。방법선택2013년1월지2014년12월고지혈증성급성이선염환자64례。근거질병엄중정도분위경도이선염조화중도이선염조。검측응혈매원시간、활화부분응혈활매시간、섬유단백원、응혈매시간화D-이취체，병동시검측혈개。비교량조상술지표적불동급기화혈개적관계。결과경도이선염조적응혈매원시간、섬유단백원、D-이취체균명현저우중도이선염조이혈개칙상반。응혈매원시간、섬유단백원、D-이취체여혈개균위부상관(r분별위-0.338、-0.254화-0.248，P분별위0.006、0.042화0.048)。결론고지혈증성급성이선염환자적응혈매원시간、섬유단백원、D-이취체균수병정가중이승고。이혈개하강가능여응혈매원시간、섬유단백원、D-이취체상관。
Objective To profile the changes of D-dimer, coagulation indices and relation with calcium(Ca) in patients with hyperlipidemic acute pancreatitis(HLAP).Methods From Jan 2013 to Dec 2014, 64 HLAP patients were admitted to our hospital. Patients were divided into mild acute pancreatitis(MAP) group and moderately severe acute pancreatitis(MSAP)group according to the disease severity.Prothrombin time(PT),activated partial thromboplastin time, fibrinogen(Fib), thrombin time and D-dime were measured. Also, Ca were measured. Compare the difference between 2 groups and relation with Ca.Results Level of PT, Fib and D-dimer were significantly increased in MSAP group than MAP group. On the contrary, Ca was significantly decreased. PT, Fib, D-dimer were negative correlation with Ca(r=-0.338, -0.254 and -0.248, P=0.006, 0.042 and 0.048, respectively).Conclusions PT, Fib and D-dimer are increased with severity of HLAP. Decreased Ca may have correlation with increased PT, Fib and D-dimer in HLAP patients.