CAJ | 학술논문

苯丙胺类兴奋剂( amphetamine-type stimulants,ATS)是一组以精神依赖为主的新型合成毒品,近年来流行,滥用趋势愈发严峻。 MicroRNAs( MiRNAs)作为一类非编码小分子RNAs,通过与靶基因mRNA的互补配对,在转录后水平上对基因的表达进行负调控,从而导致靶基因mRNA的降解或翻译抑制。 ATS能诱导miRNAs表达水平的变化,而成瘾相关脑区miRNAs表达的改变直接参与了对ATS成瘾行为的调节。因此,研究miRNAs在ATS成瘾中的调控作用,对进一步揭示新型毒品的成瘾机制及发现新的药物作用靶点具有重要意义。
분병알류흥강제( amphetamine-type stimulants,ATS)시일조이정신의뢰위주적신형합성독품,근년래류행,람용추세유발엄준。 MicroRNAs( MiRNAs)작위일류비편마소분자RNAs,통과여파기인mRNA적호보배대,재전록후수평상대기인적표체진행부조공,종이도치파기인mRNA적강해혹번역억제。 ATS능유도miRNAs표체수평적변화,이성은상관뇌구miRNAs표체적개변직접삼여료대ATS성은행위적조절。인차,연구miRNAs재ATS성은중적조공작용,대진일보게시신형독품적성은궤제급발현신적약물작용파점구유중요의의。
Amphetamine-type stimulants ( ATS ) , a group of new-type synthetic drugs mainly in psychological dependence, are abused more and more severely in recent years. MicroRNAs ( MiRNAs ) are an important class of endogenous non-coding small RNAs that mediate posttranscriptional negatively regulation of gene expression by targeting specific mRNA sequences to in-hibit the translation of mRNAs or degrade the expression of mR-NAs. ATS can induce the changes in the expression of miRNAs in addiction-related brain regions which directly involve in the regulation of ATS-induced addictive behaviors. Therefore, to study the regulatory role of miRNAs in ATS-induced addiction has important implications for dependent mechanisms of new-type drugs and the discovery of the new targets of drug actions.