CAJ | 학술논문

蛋白质乙酰化修饰对基本生命现象进行广泛调节，如心血管稳态和肿瘤发生。探索乙酰化修饰机制及其在疾病中的异常表现，已成为医学研究的基本问题之一。血管衰老与老年性高血压、冠状动脉粥样硬化等疾病的发生发展密不可分，内皮细胞衰老是其中的关键环节。该文综述了血管衰老的乙酰化调节研究进展，并对该领域的研究做展望。
단백질을선화수식대기본생명현상진행엄범조절，여심혈관은태화종류발생。탐색을선화수식궤제급기재질병중적이상표현，이성위의학연구적기본문제지일。혈관쇠로여노년성고혈압、관상동맥죽양경화등질병적발생발전밀불가분，내피세포쇠로시기중적관건배절。해문종술료혈관쇠로적을선화조절연구진전，병대해영역적연구주전망。
Protein acetylation extensively regulates fundamental biological process, such as cardiovascular homeostasis and tu-morigenesis. Mechanism of protein acetylation and its abnormal changes during diseases has become one of the basic questions in medical research. Vascular aging is inseparable from the occur-rence and development of senile hypertension and coronary ather-osclerosis. Endothelial cell senescence plays a key role during this process. This paper reviews the research progress in acetyla-tion regulation during vascular aging, and the prospects of the re-search in this field.