CAJ | 학술논문

目的：探讨艾迪注射液辅助GP 化疗方法对晚期非小细胞肺癌（NSCLC）近期疗效、毒副反应和免疫功能的影响。方法：130例晚期NSCLC 患者根据治疗方法分为研究组和对照组，研究组给予艾迪注射液＋GP，对照组仅给予GP 治疗。比较两组的近期疗效、Ⅲ～Ⅳ级毒副反应和免疫功能的变化。结果：研究组总缓解率为40．28％，对照组为37．93％，差异无统计学意义（P＞0．05）；两组白细胞下降、胃肠道反应和血小板下降发生率比较差异具有统计学意义（P＜0．05）；研究组治疗前后的CD4、CD8和CD4／CD8变化并不明显，差异无统计学意义（P＞0．05）；对照组治疗前后CD4、CD8和CD4／CD8比较差异均具有统计学意义（P＜0．05）。两组治疗后比较差异均具有统计学意义（P＜0．05）。结论：艾迪注射液辅助GP 化疗方案治疗晚期NSCLC，其近期疗效与单纯化疗相似，但却能明显降低毒副反应发生率，避免免疫功能降低。
목적：탐토애적주사액보조GP 화료방법대만기비소세포폐암（NSCLC）근기료효、독부반응화면역공능적영향。방법：130례만기NSCLC 환자근거치료방법분위연구조화대조조，연구조급여애적주사액＋GP，대조조부급여GP 치료。비교량조적근기료효、Ⅲ～Ⅳ급독부반응화면역공능적변화。결과：연구조총완해솔위40．28％，대조조위37．93％，차이무통계학의의（P＞0．05）；량조백세포하강、위장도반응화혈소판하강발생솔비교차이구유통계학의의（P＜0．05）；연구조치료전후적CD4、CD8화CD4／CD8변화병불명현，차이무통계학의의（P＞0．05）；대조조치료전후CD4、CD8화CD4／CD8비교차이균구유통계학의의（P＜0．05）。량조치료후비교차이균구유통계학의의（P＜0．05）。결론：애적주사액보조GP 화료방안치료만기NSCLC，기근기료효여단순화료상사，단각능명현강저독부반응발생솔，피면면역공능강저。
Objective:To study the short-term effects,toxic side effects and immune function of Aidi injection adjuvant GP methods chemotherapy for advanced non-small cell lung cancer(NSCLC).Methods:130 patients with advanced NSCLC were divided into study group and the control group according to treatment methods.The study group were given Aidi injection +GP,and the control group only treated with GP.The short-term effects,toxic side effects gradeⅢ-Ⅳand immune function changes were compared between the two groups.Results:The overall response rate was 40.28%in study group,higher than 37.93% in control group(P>0.05).The two groups showed differences in the rates of leucocyte decrease,gastrointestinal reaction and platelets decrease(P<0.05).The levels of CD4,CD8 and CD4/CD8 didn′t changed obviously in study group(P>0.05),while in the control group the levels of CD4,CD8 and CD4/CD8 changed more significantly than before(P<0.05).The two groups also produced differences in CD4,CD8 and CD4/CD8 after treatment( P<0.05 ) .Conclusion: The short-term effects of Aidi injection adjuvant GP chemotherapy regimen for advanced NSCLC is similar to only GP chemotherapy,but it can obviously reduce the incidence of toxic side effects and prevent the immune func-tion.