CAJ | 학술논문

目的：探讨2型糖尿病（T2DM ）患者血清游离脂肪酸（FFA ）水平与胰岛素抵抗的相关性。方法选取102例T2DM患者作为T2DM组，依据糖化血红蛋白（HbA1c）水平分为控制良好和控制不良组，选取62例健康体检者作为健康对照组，检测各组的 HbA1c、三酰甘油（TG）、空腹血糖（FBS）、餐后2 h血糖（PPBS）、空腹胰岛素（FINS）、空腹 FFA 及餐后2 h游离脂肪酸（2hFFA）。以稳态模式评估胰岛素抵抗指数（HOMA‐IR）。结果T2DM 组HbA1c、TG、FBS、PPBS、FFA、2hFFA及 HOMA‐IR均较健康对照组明显升高（P＜0．05）。 T2DM 控制不良组各指标均高于控制良好组（P＜0．05）。FFA、2hFFA与其他指标均呈明显正相关（r＞0．5，P＜0．01）。结论T2DM患者体内FFA水平显著升高，与胰岛素抵抗存在明显相关性。
목적：탐토2형당뇨병（T2DM ）환자혈청유리지방산（FFA ）수평여이도소저항적상관성。방법선취102례T2DM환자작위T2DM조，의거당화혈홍단백（HbA1c）수평분위공제량호화공제불량조，선취62례건강체검자작위건강대조조，검측각조적 HbA1c、삼선감유（TG）、공복혈당（FBS）、찬후2 h혈당（PPBS）、공복이도소（FINS）、공복 FFA 급찬후2 h유리지방산（2hFFA）。이은태모식평고이도소저항지수（HOMA‐IR）。결과T2DM 조HbA1c、TG、FBS、PPBS、FFA、2hFFA급 HOMA‐IR균교건강대조조명현승고（P＜0．05）。 T2DM 공제불량조각지표균고우공제량호조（P＜0．05）。FFA、2hFFA여기타지표균정명현정상관（r＞0．5，P＜0．01）。결론T2DM환자체내FFA수평현저승고，여이도소저항존재명현상관성。
Objective To investigate the relationship of serum free fatty acid (FFA ) level and insulin resist‐ance in patients with type 2 diabetes mellitus (T2DM ) .Methods A total of 102 T2DM patients were enrolled (T2DM group) ,and divided into well‐control group and poor‐control group according to their glycosylated hemoglo‐bin (HbA1c) levels .Moreover ,62 healthy people were recruited as normal control group .All of the subjects were un‐derwent measurement of triglyceride (TG ) ,HbA1c ,fast blood glucose (FBS ) ,2 h postprandial blood glucose (PPBS) ,fast insulin (FINS) ,fast FFA and 2 h postprandial FFA (2hFFA) .And the insulin resistance index (HO‐MA‐IR) was evaluated by homeostasis model .Results The levels of HbA1c ,TG ,FBS ,PPBS ,FFA ,2hFFA and HO‐MA‐IR in T2DM group were significantly higher than those in normal control group (P<0 .05) .And these parame‐ters in poor‐control group were higher than those in well‐control group(P<0 .05) .FFA and 2hFFA were positively correlated with other parameters (r>0 .5 ,P<0 .01) .Conclusion The serum level of FFA increased in T 2DM pa‐tients ,which related with insulin resistance .