CAJ | 학술논문

目的：探索复方三七吴茱萸滴丸的制备工艺。方法：通过三七吴茱萸滴丸制备实验，用单因素和正交实验的方法，以滴丸的成型性、圆整度、硬度、重量差异、崩解时限为筛选指标，以基质的选择、药物与基质的配比、药液的保温温度、冷凝剂、冷凝剂的温度、滴头内外径大小、滴距、滴制速度为主要考察因素，对三七吴茱萸滴丸的制备工艺进行优选，并用 HPLC 法对最佳的优选结果进行含量测定。结果：基质为PEG4000：PEG6000＝3∶1，药物与基质的最佳配比为1∶5，滴制温度为80℃，冷凝剂为甲基硅油，冷凝剂温度为12℃，滴头内外径大小为3.7/4.4mm，滴距为20cm，滴速为40滴/min，用HPLC法测定三七吴茱萸滴丸中三七皂苷R1、吴茱萸次碱的含量分别为：0.578%、9.429×10-3%。结论：该工艺制备的滴丸的成型效果最佳。
목적：탐색복방삼칠오수유적환적제비공예。방법：통과삼칠오수유적환제비실험，용단인소화정교실험적방법，이적환적성형성、원정도、경도、중량차이、붕해시한위사선지표，이기질적선택、약물여기질적배비、약액적보온온도、냉응제、냉응제적온도、적두내외경대소、적거、적제속도위주요고찰인소，대삼칠오수유적환적제비공예진행우선，병용 HPLC 법대최가적우선결과진행함량측정。결과：기질위PEG4000：PEG6000＝3∶1，약물여기질적최가배비위1∶5，적제온도위80℃，냉응제위갑기규유，냉응제온도위12℃，적두내외경대소위3.7/4.4mm，적거위20cm，적속위40적/min，용HPLC법측정삼칠오수유적환중삼칠조감R1、오수유차감적함량분별위：0.578%、9.429×10-3%。결론：해공예제비적적환적성형효과최가。
Objective: To explore the best forming techniques for the Fufang Sanqi Wuzhuyu Wan. Methods: By single factor and orthogonal test, the formations, roundness, hardness, weight variation, the disintegration time of Sanqi Wuzhuyu Wan were selected as the screening index; and the type of base material, the temperature of physic liquor, the ratio of drug to base material, the type of the cooling agent, the temperature of the cooling agent, the diameters of dropper, the distance, the speed were selected as the main factors; the best forming techniques for the Fufang Sanqi Wuzhuyu Wan was selected. Then HPLC was used to determine the content of the best optimized results. Results: The ratio of base material (PEG4000∶PEG6000) was 3∶1, the ratio of drug to base material was 1∶5, the temperature of drug solution was 80℃, the cooling agent was methyl silicone oil, the temperature of the cooling agent was 12℃, the diameters of dropper was 3.7/4.4 mm, the distance was 20cm,the speed was 40 drops per min. The content of notoginsenoside R1 and rutaecarpine in the Fufang Sanqi Wuzhuyu Wan was 0.578% and 9.429×10-3%. Conclusion: The preparation method was the optimum forming condition.