中华临床免疫和变态反应杂志
中華臨床免疫和變態反應雜誌
중화림상면역화변태반응잡지
Chinese Journal of Allergy & Clinical Immunology
2015年
3期
172-176
,共5页
汪汉%杨萌萌%罗莲%刘汉雄%周名纲%熊信林%李锦%蔡琳
汪漢%楊萌萌%囉蓮%劉漢雄%週名綱%熊信林%李錦%蔡琳
왕한%양맹맹%라련%류한웅%주명강%웅신림%리금%채림
皮肌炎%心包积液%危险因素%超声心动图
皮肌炎%心包積液%危險因素%超聲心動圖
피기염%심포적액%위험인소%초성심동도
dermatomyositis%pericardial effusion%risk factors%echocardiography
目的：分析皮肌炎合并心包积液的临床特点及危险因素。方法采用回顾性病例对照研究的方法调查皮肌炎合并心包积液的临床特点与危险因素。结果共纳入97例皮肌炎患者，其中12例（12.37％）皮肌炎患者合并心包积液；与未合并心包积液者相比，合并心包积液者舒张压[（78.67±10.19）mm Hg vs.（70.33±11.80）mm Hg，P ＝0.022]、血尿酸水平[（420.25±153.31）μmol？L vs.（291.89±101.44）μmol？L，P ＝0.000]及及主肺动脉内径[（22.08±2.28）mm vs.（19.95±2.49）mm，P ＝0.006]均较高；皮肌炎合并心包积液与主肺动脉内径（P ＝0.039，OR ＝1.328，95％ CI：1.015～1.738）和血尿酸水平（P ＝0.010，OR ＝1.007，95％ CI：1.002～1.013）相关；受试者工作曲线显示主肺动脉内径及血尿酸曲线下面积分别为0.756（P ＝0.004，95％ CI：0.626～0.886）、0.773（P ＝0.002，95％ CI：0.612～0.934），同时存在对心包积液判定有意义的截点。结论皮肌炎合并心包积液并不少见，其发生机制有待进一步探讨。
目的：分析皮肌炎閤併心包積液的臨床特點及危險因素。方法採用迴顧性病例對照研究的方法調查皮肌炎閤併心包積液的臨床特點與危險因素。結果共納入97例皮肌炎患者，其中12例（12.37％）皮肌炎患者閤併心包積液；與未閤併心包積液者相比，閤併心包積液者舒張壓[（78.67±10.19）mm Hg vs.（70.33±11.80）mm Hg，P ＝0.022]、血尿痠水平[（420.25±153.31）μmol？L vs.（291.89±101.44）μmol？L，P ＝0.000]及及主肺動脈內徑[（22.08±2.28）mm vs.（19.95±2.49）mm，P ＝0.006]均較高；皮肌炎閤併心包積液與主肺動脈內徑（P ＝0.039，OR ＝1.328，95％ CI：1.015～1.738）和血尿痠水平（P ＝0.010，OR ＝1.007，95％ CI：1.002～1.013）相關；受試者工作麯線顯示主肺動脈內徑及血尿痠麯線下麵積分彆為0.756（P ＝0.004，95％ CI：0.626～0.886）、0.773（P ＝0.002，95％ CI：0.612～0.934），同時存在對心包積液判定有意義的截點。結論皮肌炎閤併心包積液併不少見，其髮生機製有待進一步探討。
목적：분석피기염합병심포적액적림상특점급위험인소。방법채용회고성병례대조연구적방법조사피기염합병심포적액적림상특점여위험인소。결과공납입97례피기염환자，기중12례（12.37％）피기염환자합병심포적액；여미합병심포적액자상비，합병심포적액자서장압[（78.67±10.19）mm Hg vs.（70.33±11.80）mm Hg，P ＝0.022]、혈뇨산수평[（420.25±153.31）μmol？L vs.（291.89±101.44）μmol？L，P ＝0.000]급급주폐동맥내경[（22.08±2.28）mm vs.（19.95±2.49）mm，P ＝0.006]균교고；피기염합병심포적액여주폐동맥내경（P ＝0.039，OR ＝1.328，95％ CI：1.015～1.738）화혈뇨산수평（P ＝0.010，OR ＝1.007，95％ CI：1.002～1.013）상관；수시자공작곡선현시주폐동맥내경급혈뇨산곡선하면적분별위0.756（P ＝0.004，95％ CI：0.626～0.886）、0.773（P ＝0.002，95％ CI：0.612～0.934），동시존재대심포적액판정유의의적절점。결론피기염합병심포적액병불소견，기발생궤제유대진일보탐토。
Objective To analyze the clinical risk factors for pericardial effusion (PE )in dermatomyositis. Methods Case-control trial was carried out to assess the risk factors for PE in dermatomyositis.Results Ninety-seven dermatomyositis patients were retrospectively enrolled from a cardiovascular center.12.37% of dermatomyosits patients had pericardial effusion,who had higher diastolic blood pressure [(78.67 ± 10.19)mm Hg vs.(70.33 ±11.80)mm Hg,P =0.022],uric acid (UA)level [(420.25 ±153.31 )μmol?L vs.(291.89 ±101.44)μmol?L,P =0.000],and main pulmonary artery diameter (MPAD) [(22.08 ±2.28)mm vs.(19.95 ±2.49)mm,P =0.006]when compared to those without PE.Logistic regression model demonstrated that UA (P =0.010,OR =1.007,95% CI:1.002 -1.013),and MPAD (P =0.039,OR =1.328,95% CI: 1.015 -1.738 ) were associated with pericardial effusion in dermatomyositis.Receiver operation characteristic curve revealed the area under curve of UA and MPAD were 0.756 (P =0.004,95%CI:0.626 -0.886)and 0.773 (P =0.002,95%CI:0.612 -0.934), respectively.Conclusion Pericarial effusion is not uncommon,which is associated with UA and MPAD in dermatomyosits.These factors would help to assess the presence of.
