CAJ | 학술논문

心肌缺血/再灌注损伤是缺血心肌获得最佳疗效的主要障碍，目前临床中还无有效药物进行预防和治疗。三七是传统的化瘀止痛药物，临床中常用于治疗心绞痛、冠心病等，随着研究的深入，发现三七及其提取物能够调控多种信号通路，对心肌缺血/再灌注损伤产生保护作用，具有较广阔的应用前景。该文综述了近年来三七及其活性成分对心肌缺血/再灌注损伤的治疗作用及作用机制，以期为后期药物开发提供参考。
심기결혈/재관주손상시결혈심기획득최가료효적주요장애，목전림상중환무유효약물진행예방화치료。삼칠시전통적화어지통약물，림상중상용우치료심교통、관심병등，수착연구적심입，발현삼칠급기제취물능구조공다충신호통로，대심기결혈/재관주손상산생보호작용，구유교엄활적응용전경。해문종술료근년래삼칠급기활성성분대심기결혈/재관주손상적치료작용급작용궤제，이기위후기약물개발제공삼고。
Myocardial ischemia/reperfusion injury ( MI/RI) is a pathophysiological phenomenon commonly seen during thromboly-sis, percutaneous transluminal coronary angioplasty ( PTCA ) , and coronary artery bypass grafting ( CABG ) . It is defined as restoration of blood flow to a previously ischemic region followed by complex pathological events leading to tissue injury greater than the original ischemic insult. Many experimental interven-tions have been reported to protect the ischemic myocardium in experimental animals; however, with the exception of early reperfusion, none has been translated into clinical practice. The root of Panax notoginseng ( Burk. ) F. H. Chen ( PN) is one of the iconic herbs in traditional Chinese medicine. Traditional pharmacopeia recommended it among the most efficacious herbs for‘promoting blood circulation ’ and hemostasis. Inspired by this, in the last decade, a large number of modern investigators made substantial efforts to search the PN activities against a vari-ety of MIRI. The systematic review was performed according to the protecting drug of the MIRI development guidelines.