CAJ | 학술논문

RhoA属于小 G 蛋白 Rho 亚家族，在细胞的增殖、迁移、黏附及凋亡等过程中发挥重要的调控作用。国内外近期研究发现，一方面RhoA/ROCK通路可通过影响心肌能量代谢、炎症反应、内质网应激等在心肌缺血/再灌注中造成心肌损伤，另一方面， RhoA的激活对再灌注损伤也具有积极作用。该文对近年来RhoA在心肌缺血/再灌注中的调控作用及机制作一综述，并探讨其作为治疗心肌缺血/再灌注损伤的药物靶点的应用前景，为研发心肌缺血/再灌注损伤治疗药物及其用药策略提供理论依据。
RhoA속우소 G 단백 Rho 아가족，재세포적증식、천이、점부급조망등과정중발휘중요적조공작용。국내외근기연구발현，일방면RhoA/ROCK통로가통과영향심기능량대사、염증반응、내질망응격등재심기결혈/재관주중조성심기손상，령일방면， RhoA적격활대재관주손상야구유적겁작용。해문대근년래RhoA재심기결혈/재관주중적조공작용급궤제작일종술，병탐토기작위치료심기결혈/재관주손상적약물파점적응용전경，위연발심기결혈/재관주손상치료약물급기용약책략제공이론의거。
RhoA belongs to the small G binding proteins Rho subfamily, playing an important role in the various cellular func-tions, including migration, proliferation, adhesion and apopto-sis. Recent data indicate that RhoA/ROCK pathway causes myo-cardial damage by influencing the myocardial energy metabolism, inflammation, and endoplasmic reticulum stress. On the other hand, the activation of RhoA also has a positive role in MIRI. This article reviews the regulatory effect of RhoA on MIRI and its mechanisms, discusses the prospects of RhoA as a novel thera-peutic target for MIRI, and provides new therapeutic treatments and strategies for MIRI.