中国药理学通报
中國藥理學通報
중국약이학통보
Chinese Pharmacological Bulletin
2015年
10期
1333-1335,1336
,共4页
陶羽%刘兆国%季律%王燕%王晓钰%包凯帆%王璨%于曦%刘海亮%洪敏%江国荣
陶羽%劉兆國%季律%王燕%王曉鈺%包凱帆%王璨%于晞%劉海亮%洪敏%江國榮
도우%류조국%계률%왕연%왕효옥%포개범%왕찬%우희%류해량%홍민%강국영
E-钙粘蛋白%支气管哮喘%气道上皮细胞%黏附分子%异常表达%分子机制
E-鈣粘蛋白%支氣管哮喘%氣道上皮細胞%黏附分子%異常錶達%分子機製
E-개점단백%지기관효천%기도상피세포%점부분자%이상표체%분자궤제
E-cadherin%bronchial asthma%airway epithelial cells%adhesion molecules%abnormal expression%molecular mechanisms
支气管哮喘是一种严重影响人们生活质量的呼吸系统疾病,多种因素介导该病的发生与发展,其中尤以E-钙粘蛋白(E-cadherin, E-cad)的异常表达最为关键。研究发现,E-cad是一种重要的细胞黏附分子,其主要功能在于维持细胞之间的结构完整性以及参与改善气道的重塑和免疫功能的修复。进一步研究表明,支气管哮喘患者的气道上皮细胞其粘膜屏障功能常常遭受破坏,且黏膜分子E-cad的表达明显降低,这表明E-cad的异常表达参与了支气管哮喘的发生。该文对近年来E-cad的异常表达与支气管哮喘研究进展进行综述,重点对E-cad异常表达介导支气管哮喘发生发展的分子机制进行概述,并对靶向E-cad治疗支气管哮喘的策略进行探讨,为临床的后续研究和治疗提供参考。
支氣管哮喘是一種嚴重影響人們生活質量的呼吸繫統疾病,多種因素介導該病的髮生與髮展,其中尤以E-鈣粘蛋白(E-cadherin, E-cad)的異常錶達最為關鍵。研究髮現,E-cad是一種重要的細胞黏附分子,其主要功能在于維持細胞之間的結構完整性以及參與改善氣道的重塑和免疫功能的脩複。進一步研究錶明,支氣管哮喘患者的氣道上皮細胞其粘膜屏障功能常常遭受破壞,且黏膜分子E-cad的錶達明顯降低,這錶明E-cad的異常錶達參與瞭支氣管哮喘的髮生。該文對近年來E-cad的異常錶達與支氣管哮喘研究進展進行綜述,重點對E-cad異常錶達介導支氣管哮喘髮生髮展的分子機製進行概述,併對靶嚮E-cad治療支氣管哮喘的策略進行探討,為臨床的後續研究和治療提供參攷。
지기관효천시일충엄중영향인문생활질량적호흡계통질병,다충인소개도해병적발생여발전,기중우이E-개점단백(E-cadherin, E-cad)적이상표체최위관건。연구발현,E-cad시일충중요적세포점부분자,기주요공능재우유지세포지간적결구완정성이급삼여개선기도적중소화면역공능적수복。진일보연구표명,지기관효천환자적기도상피세포기점막병장공능상상조수파배,차점막분자E-cad적표체명현강저,저표명E-cad적이상표체삼여료지기관효천적발생。해문대근년래E-cad적이상표체여지기관효천연구진전진행종술,중점대E-cad이상표체개도지기관효천발생발전적분자궤제진행개술,병대파향E-cad치료지기관효천적책략진행탐토,위림상적후속연구화치료제공삼고。
Bronchial asthma is a kind of respiratory disease which affects people 's life quality seriously. Many factors in-volved in the occurrence and development of such disease, of which the aberrant expression of E-cad plays a critical role in it. Research found that E-cad is an important cell adhesion molecu-lar, and its main function is to maintain the structural integrity of cells and participate in the improvement of airway remodeling as well as restoration of immune function. Further study showed that the role of mucosal barrier of airway epithelial cells in bronchial asthma patients was often damaged. Moreover, the protein ex-pression of E-cad decreased significantly in mucosal molecular, which suggested that the abnormal expression of E-cad was in-volved in the development of bronchial asthma. A review on the relations between the abnormal expression of E-cad protein and bronchial asthma has been discussed in this paper, also it in-cludes the discussion about the mechanisms of E-cad’ s disorder-induced bronchial asthma as well as explores the strategies of bronchial asthma treatment, which may provide references for the follow-up research and clinical treatment.
