CAJ | 학술논문

目的：分析2011～2013年徐州医学院附属医院检验科临床分离的肠杆菌科细菌对常用抗菌药物的耐药情况及变化趋势。方法收集该院2011～2013年临床首次分离的肠杆菌科细菌6498株，采用全自动微生物分析仪进行鉴定和药敏试验，采用WHONET5．6软件分析耐药情况。结果6498株肠杆菌科细菌主要为肺炎克雷伯菌、阴沟肠杆菌、奇异变形杆菌和产气肠杆菌等，主要来自IC U、神经内科、神经外科、呼吸内科等，送检标本主要为痰液、尿液和血液等。亚胺培南对肠杆菌科细菌敏感率较高，但碳青霉烯类耐药肠杆菌科细菌已经出现。结论该院肠杆菌科细菌对多数抗菌药物敏感率较低，且对碳青霉烯类抗菌药物耐药的菌株有增多趋势。
목적：분석2011～2013년서주의학원부속의원검험과림상분리적장간균과세균대상용항균약물적내약정황급변화추세。방법수집해원2011～2013년림상수차분리적장간균과세균6498주，채용전자동미생물분석의진행감정화약민시험，채용WHONET5．6연건분석내약정황。결과6498주장간균과세균주요위폐염극뢰백균、음구장간균、기이변형간균화산기장간균등，주요래자IC U、신경내과、신경외과、호흡내과등，송검표본주요위담액、뇨액화혈액등。아알배남대장간균과세균민감솔교고，단탄청매희류내약장간균과세균이경출현。결론해원장간균과세균대다수항균약물민감솔교저，차대탄청매희류항균약물내약적균주유증다추세。
Objective To analyze the drug resistance situation of clinically isolated Enterobacteria bacteria to commonly used antimicrobial agents in the clinical laboratory department of Affiliated Hospital of Xuzhou Medical College during 2011-2013 .Methods 6 498 strains of Enterobacteriaceae bacteria were collected from this hospital during 2011-2013 .The identification and drug susceptibility test were performed by adopting the automatic microor‐ganism analyzer .The drug resistance situation was analyzed by adopting the WHONET 5 .6 software .Results 6 498 strains of Enterobacteriaceae bacteria mainly included Klebsiella pneumoniae ,Escherichia coli ,Enterobacter cloacae , Proteus mirabilis and Enterobacter aerogenes ,mainly derived from ICU ,neurology ,neurosurgery and respiratory medicine departments ,and the submitted specimens mainly were sputum ,urine and blood .Most bacteria possessed higher sensitivity rate to imipenem ,but carbopenem‐resistant Enterobacteriaceae bacteria already appeared .Conclusion Enterobacteriaceae bacteria isolated from this hospital have lower sensitivity rates to most antimicrobial agents , moreover the strains of carbapenem‐resistant Enterobacteriaceae bacteria show the increasing trend .