中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
Chinese Journal of Practical Ophthalmology
2015年
8期
857-861
,共5页
刘院斌%张学敏%张丰菊%张淼%邹迎%王宁利
劉院斌%張學敏%張豐菊%張淼%鄒迎%王寧利
류원빈%장학민%장봉국%장묘%추영%왕저리
主观感觉%0.1％溴芬酸钠水合物滴眼液%0.1％双氯芬酸钠滴眼液组%准分子激光角膜原位磨镶术
主觀感覺%0.1％溴芬痠鈉水閤物滴眼液%0.1％雙氯芬痠鈉滴眼液組%準分子激光角膜原位磨鑲術
주관감각%0.1％추분산납수합물적안액%0.1％쌍록분산납적안액조%준분자격광각막원위마양술
Subjective feeling%0.1％bromfenac sodium hydrate ophthalmic solution%0.1％Diclofenac sodium ophthalmic solution%Laser in situ keratomileusis
目的 评估0.1％溴芬酸钠水合物滴眼液与0.1％双氯芬酸钠滴眼液在飞秒辅助下准分子激光原位角膜磨镶术(FS-LASIK)后早期镇痛效果.方法 临床病例对照研究.对2013年10月至2014年8月在北京同仁医院屈光中心选取双眼行FS-LASIK术的患者195例,根据患者就诊顺序按照奇偶数法随机分为3组:所有患者术前3d开始均常规局部使用0.5％左氧氟沙星滴眼液(4次/d);0.1％溴芬酸钠水合物滴眼液组64例128只眼,术前3d开始加用0.1％溴芬酸钠水合物滴眼液(2次/d);0.1％双氯芬酸钠滴眼液组61例122只眼,术前3d开始加用0.1％双氯芬酸钠滴眼液(4次/d);对照组70例140只眼,术前3d不使用非甾体抗炎药.所有患者术后1d复查,调查患者的主观感觉(包括疼痛感、烧灼感、异物感、干涩感、视疲劳).患者主观感觉根据程度分为0、1、2、3分,分别表示无、轻度、中度、重度.结果 在LASIK术后早期患者疼痛和干涩感评分3组之间总体差异均有统计学意义(右眼F =5.11,84.29;左眼F=4.64,83.29;P＜0.05);0.1％溴芬酸钠水合物滴眼液组与0.1％双氯芬酸钠滴眼液组之间差异均无统计学意义(右眼g =1.1317,0.1201;左眼q=1.2312,0.8479;P＞0.05);0.1％溴芬酸钠水合物滴眼液组与对照组之间差异均有统计学意义(右眼q=4.3490,15.9102;左眼q=4.1853,16.1668;P＜0.05);0.1％双氯芬酸钠滴眼液组与对照组之间差异均有统计学意义(右眼q=3.1381,15.5869;左眼q=2.8748,15.0968;P＜0.05).在烧灼感、异物感、视疲劳评分3组之间总体差异均无统计学差异(右眼F =1.66,0.61,1.43;左眼F=2.29,0.82,1.07;P＞0.05).每组双眼之间的差异均无统计学意义(P＞0.05).结论 0.1％溴芬酸钠水合物滴眼液与0.1％双氯芬酸钠滴眼液对FS-LASIK术后的早期疼痛和干涩感治疗方面可达到相似的效果.术后早期使用此两种药物在镇痛和防干涩感均优于常规用药组.
目的 評估0.1％溴芬痠鈉水閤物滴眼液與0.1％雙氯芬痠鈉滴眼液在飛秒輔助下準分子激光原位角膜磨鑲術(FS-LASIK)後早期鎮痛效果.方法 臨床病例對照研究.對2013年10月至2014年8月在北京同仁醫院屈光中心選取雙眼行FS-LASIK術的患者195例,根據患者就診順序按照奇偶數法隨機分為3組:所有患者術前3d開始均常規跼部使用0.5％左氧氟沙星滴眼液(4次/d);0.1％溴芬痠鈉水閤物滴眼液組64例128隻眼,術前3d開始加用0.1％溴芬痠鈉水閤物滴眼液(2次/d);0.1％雙氯芬痠鈉滴眼液組61例122隻眼,術前3d開始加用0.1％雙氯芬痠鈉滴眼液(4次/d);對照組70例140隻眼,術前3d不使用非甾體抗炎藥.所有患者術後1d複查,調查患者的主觀感覺(包括疼痛感、燒灼感、異物感、榦澀感、視疲勞).患者主觀感覺根據程度分為0、1、2、3分,分彆錶示無、輕度、中度、重度.結果 在LASIK術後早期患者疼痛和榦澀感評分3組之間總體差異均有統計學意義(右眼F =5.11,84.29;左眼F=4.64,83.29;P＜0.05);0.1％溴芬痠鈉水閤物滴眼液組與0.1％雙氯芬痠鈉滴眼液組之間差異均無統計學意義(右眼g =1.1317,0.1201;左眼q=1.2312,0.8479;P＞0.05);0.1％溴芬痠鈉水閤物滴眼液組與對照組之間差異均有統計學意義(右眼q=4.3490,15.9102;左眼q=4.1853,16.1668;P＜0.05);0.1％雙氯芬痠鈉滴眼液組與對照組之間差異均有統計學意義(右眼q=3.1381,15.5869;左眼q=2.8748,15.0968;P＜0.05).在燒灼感、異物感、視疲勞評分3組之間總體差異均無統計學差異(右眼F =1.66,0.61,1.43;左眼F=2.29,0.82,1.07;P＞0.05).每組雙眼之間的差異均無統計學意義(P＞0.05).結論 0.1％溴芬痠鈉水閤物滴眼液與0.1％雙氯芬痠鈉滴眼液對FS-LASIK術後的早期疼痛和榦澀感治療方麵可達到相似的效果.術後早期使用此兩種藥物在鎮痛和防榦澀感均優于常規用藥組.
목적 평고0.1％추분산납수합물적안액여0.1％쌍록분산납적안액재비초보조하준분자격광원위각막마양술(FS-LASIK)후조기진통효과.방법 림상병례대조연구.대2013년10월지2014년8월재북경동인의원굴광중심선취쌍안행FS-LASIK술적환자195례,근거환자취진순서안조기우수법수궤분위3조:소유환자술전3d개시균상규국부사용0.5％좌양불사성적안액(4차/d);0.1％추분산납수합물적안액조64례128지안,술전3d개시가용0.1％추분산납수합물적안액(2차/d);0.1％쌍록분산납적안액조61례122지안,술전3d개시가용0.1％쌍록분산납적안액(4차/d);대조조70례140지안,술전3d불사용비치체항염약.소유환자술후1d복사,조사환자적주관감각(포괄동통감、소작감、이물감、간삽감、시피로).환자주관감각근거정도분위0、1、2、3분,분별표시무、경도、중도、중도.결과 재LASIK술후조기환자동통화간삽감평분3조지간총체차이균유통계학의의(우안F =5.11,84.29;좌안F=4.64,83.29;P＜0.05);0.1％추분산납수합물적안액조여0.1％쌍록분산납적안액조지간차이균무통계학의의(우안g =1.1317,0.1201;좌안q=1.2312,0.8479;P＞0.05);0.1％추분산납수합물적안액조여대조조지간차이균유통계학의의(우안q=4.3490,15.9102;좌안q=4.1853,16.1668;P＜0.05);0.1％쌍록분산납적안액조여대조조지간차이균유통계학의의(우안q=3.1381,15.5869;좌안q=2.8748,15.0968;P＜0.05).재소작감、이물감、시피로평분3조지간총체차이균무통계학차이(우안F =1.66,0.61,1.43;좌안F=2.29,0.82,1.07;P＞0.05).매조쌍안지간적차이균무통계학의의(P＞0.05).결론 0.1％추분산납수합물적안액여0.1％쌍록분산납적안액대FS-LASIK술후적조기동통화간삽감치료방면가체도상사적효과.술후조기사용차량충약물재진통화방간삽감균우우상규용약조.
Objective To assess early postoperative analgesia of 0.1％ bromfenac sodium hydrate ophthalmic solution and Diclofenac sodium ophthalmic solution after excimer laser in situ keratomileusis.Methods A case-control study.Form October 2013 to August 2014,195 cases were collected and performed Femtosecond laser assisted LASIK in Beijing Tongren Hospital Refractive Center.Cases were randomly grouped according to the order in which the number of patient visits using Parity Act:All patients routinely used 0.5％ levofloxacin ophthalmic solution (4 times per day).0.1％bromfenac sodium hydrate drops 64 cases (128eyes),From preoperative 3d starting they were pointed with 0.1％ bromfenac sodium hydrate drops (2 timesper day);0.1％ Diclofenac sodium ophthalmic solution 61 cases (122 eyes),From preoperative 3d starting they were pointed with 0.1％ Diclofenac sodium ophthalmic solution (4 times per day);the control group 70 cases (140 eyes),without use of non-steroidal anti-inflammatory drug.On next day after surgery,the patient's subjective feeling (Pain,burning,foreign body sensation,dryness,eye fatigue) were investigated.According to the degree of patients' subjective feeling 0,1,2,3 points represented none,mild,moderate,and severe,respectively.Results Scores about pain and dryness were statistically significant differences among the three groups (right eye F =5.11,84.29;left eye F =4.64,83.29;P ＜0.05),Differences was not statistically significant between 0.1％ bromfenac sodium hydrate group and 0.1％ diclofenac sodium groups (right eye q =1.1317,0.1201;left eye q =1.2312,0.8479;P ＞0.05);The difference were statistically significant between 0.1％ bromfenac sodium hydrate drops and control groups (right eye q =4.3490,15.9102;left eye q-4.1853,16.1668;P ＜0.05);The difference were statistically significant between 0.1％ diclofenac sodium ophthalmic solution groups and control groups (right q =3.1381,15.5869;eye q =2.8748,15.0968;P ＜0.05).Score about burning,foreign body sensation and eye fatigue difference was not statistically different between the three groups (right eye F =1.66,0.61,1.43;left eye F =2.29,0.82,1.07;P ＞0.05).Differences between the eyes in each group were not statistically significant (P ＞0.05).Conclusions On early treatment of pain and dryness after FS-LASIK,0.1％ bromfenac sodium hydrate drops aspects can achieve a similar effect with diclofenac sodium ophthalmic solution.Both drugs can release the feeling of pain and dryness due to surgery compared with control group.
