CAJ | 학술논문

目的：探讨皮肌炎常见自身抗体抗核抗体（ANA）和抗合成酶Jo‐1抗体（抗Jo‐1抗体）的临床意义。方法选取皮肌炎患者280例，分为ANA阳性且抗Jo‐1抗体阳性组（A组，70例）、ANA阳性抗Jo‐1抗体阴性组（B组，80例）、ANA阴性抗Jo‐1抗体阳性组（C组，70例）及ANA阴性且抗Jo‐1抗体阴性组（D组，60例）。分析4组患者肌酶变化情况、内脏器官损害情况及实验室相关指标特点，并分析不同ANA水平与肌酶的相关性。结果与D组比较，A组和C组患者肌酶明显升高，且肺和心脏损害发生率也明显升高（P＜0．05），而B组患者肌酶升高不明显（P＞0．05），且肌酶与ANA滴度水平变化无相关性（P＞0．05）。结论抗Jo‐1抗体能正确反映皮肌炎病情严重程度。
목적：탐토피기염상견자신항체항핵항체（ANA）화항합성매Jo‐1항체（항Jo‐1항체）적림상의의。방법선취피기염환자280례，분위ANA양성차항Jo‐1항체양성조（A조，70례）、ANA양성항Jo‐1항체음성조（B조，80례）、ANA음성항Jo‐1항체양성조（C조，70례）급ANA음성차항Jo‐1항체음성조（D조，60례）。분석4조환자기매변화정황、내장기관손해정황급실험실상관지표특점，병분석불동ANA수평여기매적상관성。결과여D조비교，A조화C조환자기매명현승고，차폐화심장손해발생솔야명현승고（P＜0．05），이B조환자기매승고불명현（P＞0．05），차기매여ANA적도수평변화무상관성（P＞0．05）。결론항Jo‐1항체능정학반영피기염병정엄중정도。
Objective To investigate the clinical significance of common autoantibodies including antinuclear antibody(ANA) and anti‐synthetase antibody(Jo‐1)in dermatomyositis .Methods 280 hospitalized patients with der‐matomyositis in our hospital were selected and divided into the ANA positive and Jo‐1 positive group(group A ,70 ca‐ses) ,ANA positive and Jo‐1 negative group(group B ,80 cases) ,ANA negative and Jo‐1 positive group(group C ,70 cases) and ANA negative and Jo‐1 negative group(group D ,60 cases) .The changes of muscle enzymes ,visceral organ damages and features of laboratory related indexes were analyzed in the four groups .Meanwhile ,the correlation be‐tween the ANA level and muscle enzymes was analyzed .Results Compared with the group D ,the muscle enzymes in the group A and C were significantly increased(P<0 .05) ,moreover the incidence of lung and heart damages also was significantly increased ,(P<0 .05) ,while the increase of muscle enzymes in the group B was unapparent (P>0 .05) , moreover the muscle enzymes had no correlation with the ANA titer level (P> 0 .05) .Conclusion Jo‐1 antibody could correctly reflect the illness severity of dermatomyositis .